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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation.
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RAD6 is upregulated in response to chemotherapy and significantly correlated with expression of ovarian cancer (OC) stem cell signaling genes ALDH1A1 (show ALDH1A1 Antibodies) and SOX2 (show SOX2 Antibodies) and poor prognosis of OC patients.
These results point to an important role of the affinity between RNF4 (show RNF4 Antibodies) and its cognate RAD6B or UBCH5B (show UBE2D2 Antibodies) in governing the multiplicity of substrate ubiquitination.
RAD6 promotes proteasome activity and nuclear translocation by enhancing the degradation of PSMF1 (show PSMF1 Antibodies) and the lamin B receptor (show LBR Antibodies).
In conclusion, we reveal that miR (show MLXIP Antibodies)-455-5p expression is regulated by the TGF-beta (show TGFB1 Antibodies)-dependent pathway, which subsequently leads to UBE2B down-regulation and contributes to oral cancer tumourigenesis.
Data show that the ubiquitin-conjugating enzyme E2 RAD6A/B-MDM2 ubiquitin ligase machinery regulates anti-silencing function 1A protein (ASF1A) degradation.
A novel variant (Chr5.133706925 A > G) residing in the UBE2B gene promoter region confers a high risk for idiopathic azoospermia in a Chinese population.
RAD6 physically interacts with heterochromatin protein 1alpha and ubiquitinates HP1alpha (show CBX5 Antibodies) at residue K154, thereby promoting heterochromatin protein 1alpha degradation through the autophagy pathway
UBE2B mRNA alterations are associated with severe oligozoospermia in infertile men.
RNF168 (show RNF168 Antibodies), in complex with RAD6A (show ube2a Antibodies) or RAD6B, is activated in the DNA-damage-induced protein ubiquitination cascade.
UBE2B polymorphisms g.-293T>G, g.20016A>G and g.9157A>G are not associated with male infertility, and the GA haplotype is likely a protective factor for male fertility in Northeast Chinese men.
These results suggest that Ube2b, as a direct androgen receptor transcriptional target in Sertoli cells, mediates the function of androgen recpetor in spermatogenesis by promoting H2A ubiquitylation.
HR6B represses major satellite repeat transcription in spermatocytes, and functions in the maintenance of X chromosome silencing in spermatocytes and spermatids.
The present findings reveal a specific requirement for the ubiquitin-conjugating activity of HR6B in relation to dynamic aspects of the synaptonemal complex and meiotic recombination in spermatocytes.
Ube2b deficient mice are shown to present male infertility and sperm head shape anomalies.
HR6B exerts control over different histone modifications in spermatocytes and spermatids, and that this function contributes to the postmeiotic maintenance of X chromosome silencing.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.
, RAD6 homolog B
, ubiquitin carrier protein B
, ubiquitin-conjugating enzyme E2 B
, ubiquitin-conjugating enzyme E2-17 kDa
, ubiquitin-conjugating enzyme E2B (RAD6 homolog)
, ubiquitin-protein ligase B
, ubiquitin conjugating enzyme
, ubiquitin-conjugating enzyme E2(14k)
, ubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae)
, ubiquitin-conjugating enzyme E2B, RAD6 homolog
, ubiquitin-conjugating enzyme E2B, RAD6 homology
, ubiquitin conjugating-protein
, Ubiquitin-conjugating enzyme E2 B
, ubiquitin-conjugating enzyme E2