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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Additionally we are shipping Ubiquitin-Conjugating Enzyme E2L 6 Proteins (15) and many more products for this protein.
Showing 10 out of 69 products:
Human Polyclonal UBE2L6 Primary Antibody for IHC (p), WB - ABIN1882146
Kumar, Kao, Howley: Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity. in The Journal of biological chemistry 1997
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Human Polyclonal UBE2L6 Primary Antibody for IHC (p), WB - ABIN388854
Krämer, Müller, Buchwald, Reichardt, Heinzel: Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARalpha. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008
Show all 3 Pubmed References
Human Monoclonal UBE2L6 Primary Antibody for ELISA, WB - ABIN563994
Zhang, Adyshev, Singleton, Li, Cepeda, Huang, Zou, Verin, Tu, Garcia, Ye: Interactions between PBEF and oxidative stress proteins--a potential new mechanism underlying PBEF in the pathogenesis of acute lung injury. in FEBS letters 2008
Cow (Bovine) Polyclonal UBE2L6 Primary Antibody for WB - ABIN2775688
Li, Wang, Yang, Li, Qin, Dong, Zhu, Liang, Liang, Han: The Spen homolog Msx2-interacting nuclear target protein interacts with the E2 ubiquitin-conjugating enzyme UbcH8. in Molecular and cellular biochemistry 2006
Depletion of either ISG15 (show ISG15 Antibodies) or UBE2L6/UBCH8 resulted in enhanced endogenous autophagic flux.
Data indicate that reduced expression of the ubiquitin-conjugating enzyme (show Ube2t Antibodies) UbcH8 (show UBE2E2 Antibodies) protein correlated with poor outcome in nasopharyngeal carcinoma (NPC (show NPC1 Antibodies)) patients.
study reports that UBCH8 (show UBE2E2 Antibodies) and UBE2G1 (show Ube2g1 Antibodies) and UBE2G2 (show UBE2G2 Antibodies) cooperate with CRL4Cdt2 in promoting the polyubiquitylation and subsequent degradation of p21 (show CDKN1A Antibodies) and Cdt1 (show CDT1 Antibodies), respectively
gain and loss-of-function approaches show that UBCH8 (show UBE2E2 Antibodies) and the ubiquitin-ligase SIAH1 physically interact with and target FLT3 (show FLT3 Antibodies)-ITD for proteasomal degradation
The structure of UbcH8 does not undergo a significant conformational change upon forming a complex with ubiquitin.
Quantitative-PCR and Northern analysis confirmed down-regulation of UCRP and UBE2L6 with BRCA2 (show BRCA2 Antibodies) knockdown, respectively.
Ube1L (show UBA7 Antibodies) was required for transfer of ISG15 (show ISG15 Antibodies) to UbcH8 (show UBE2E2 Antibodies) and for binding of Ube1L (show UBA7 Antibodies) to UbcH8 (show UBE2E2 Antibodies)
we have identified a loss-of-function mutation in Ube2l6 that contributes to the chromosome 2 obesity quantitative trait locus (show MC3R Antibodies).
Ubc8 (show UBE2H Antibodies) is a major ISG15 (show ISG15 Antibodies)-conjugating enzyme responsible for protein ISGylation upon interferon (show IFNA Antibodies) stimulation
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
ubiquitin-conjugating enzyme E2L 6
, ubiquitin/ISG15-conjugating enzyme E2 L6
, retinoic acid induced gene B protein
, retinoic acid-induced gene B protein
, ubiquitin carrier protein L6
, ubiquitin-protein ligase L6
, E2 ubiquitin conjugating enzyme
, ubiquitin-conjugating enzyme 8
, Ubiquitin carrier protein L6
, Ubiquitin-protein ligase L6