Ubiquitin-Like Modifier Activating Enzyme 5 Proteins (UBA5)

UBA5 encodes a member of the E1-like ubiquitin-activating enzyme family. Additionally we are shipping UBA5 Antibodies (40) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UBA5 79876 Q9GZZ9
Mouse UBA5 UBA5 66663 Q8VE47
UBA5 300968 Q5M7A4
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Top UBA5 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Escherichia coli (E. coli) Human His tag   50 μg Log in to see 4 Days
$385.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Human His tag 50 μg Log in to see 15 to 19 Days
$492.31
Details
Yeast Bombyx mori His tag   1 mg Log in to see 60 to 71 Days
$3,085.50
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
$3,098.33
Details
Yeast Chicken His tag   1 mg Log in to see 60 to 71 Days
$3,098.33
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,116.67
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$3,120.33
Details

UBA5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Rat (Rattus)

More Proteins for Ubiquitin-Like Modifier Activating Enzyme 5 (UBA5) Interaction Partners

Zebrafish Ubiquitin-Like Modifier Activating Enzyme 5 (UBA5) interaction partners

  1. clinical, biochemical, and experimental findings support our finding of UBA5 mutations as a pathophysiological cause for early-onset encephalopathies due to abnormal protein ufmylation

Human Ubiquitin-Like Modifier Activating Enzyme 5 (UBA5) interaction partners

  1. UFM1 (show UFM1 Proteins) His 70 resembles UBA5 His336 and enters a negatively charged pocked on the other UFM1 (show UFM1 Proteins) molecule.

  2. These findings explicitly elucidate the role of UBA5 dimerization in UFM1 (show UFM1 Proteins) activation.

  3. Heterozygous mutations in the UBA5 gene in two sisters with early-onset epileptic encephalopathy .

  4. Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy

  5. clinical, biochemical, and experimental findings support our finding of UBA5 mutations as a pathophysiological cause for early-onset encephalopathies due to abnormal protein ufmylation

  6. study provides important structural and functional insights into the interaction between UBA5 and Ub-like modifiers, improving the understanding of the biology of the ufmylation pathway.

  7. The study of UBA5-R246X revealed a dramatically decreased half-life and loss of UFM1 (show UFM1 Proteins) activation due to the absence of the catalytic cysteine Cys250.

  8. Uba5 residues 364-404 were demonstrated to be necessary for the transthiolation of Ufm1 (show UFM1 Proteins) to Ufc1 (show UFC1 Proteins), and Uba5 381-404 was identified to be the minimal region for Ufc1 (show UFC1 Proteins) recognition

  9. Crystallization of Uba5 residues 57-363 was performed at 277 K using PEG (show PAEP Proteins) 3350 as the precipitant, and crystals optimized by microseeding diffracted to 2.95 A resolution, with unit-cell parameters a=b=97.66, c=144.83 A, alpha=beta=90, gamma=120 degrees .

  10. binding of ATP to Uba5 approximately Ufm1 (show UFM1 Proteins) thioester was required for efficient transfer of Ufm1 (show UFM1 Proteins) from Uba5 to Ufc1 (show UFC1 Proteins) via transthiolation.

Mouse (Murine) Ubiquitin-Like Modifier Activating Enzyme 5 (UBA5) interaction partners

  1. The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice.

UBA5 Protein Profile

Protein Summary

This gene encodes a member of the E1-like ubiquitin-activating enzyme family. This protein activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy thioester bond. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. A pseudogene located on chromosome 1 has also been identified.

Gene names and symbols associated with UBA5

  • ubiquitin-like modifier activating enzyme 5 (uba5)
  • ubiquitin like modifier activating enzyme 5 (uba5)
  • ubiquitin like modifier activating enzyme 5 (UBA5)
  • ubiquitin-like modifier activating enzyme 5 (UBA5)
  • ubiquitin-activating enzyme E1-like protein (LOC100270786)
  • ubiquitin-like modifier activating enzyme 5 (Uba5)
  • ubiquitin like modifier activating enzyme 5 S homeolog (uba5.S)
  • 5730525G14Rik protein
  • AW240750 protein
  • cb972 protein
  • THIFP1 protein
  • UBAL protein
  • Ube1dc1 protein

Protein level used designations for UBA5

ubiquitin-activating enzyme E1-domain containing 1 , UFM1-activating enzyme , Ubiquitin-activating enzyme 5 , Ubiquitin-activating enzyme E1 domain-containing protein 1 , ubiquitin-like modifier-activating enzyme 5 , ubiquitin-like modifier activating enzyme 5 , UBA5, ubiquitin-activating enzyme E1 homolog , ubiquitin-activating enzyme 5 , ubiquitin-activating enzyme E1 domain-containing protein 1 , ubiquitin activating enzyme-like protein

GENE ID SPECIES
386712 Danio rerio
448010 Xenopus (Silurana) tropicalis
460705 Pan troglodytes
485664 Canis lupus familiaris
100270786 Bombyx mori
79876 Homo sapiens
66663 Mus musculus
300968 Rattus norvegicus
509292 Bos taurus
414879 Gallus gallus
734791 Xenopus laevis
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