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UNC5B encodes a member of the netrin family of receptors. Additionally we are shipping Unc-5 Homolog B (C. Elegans) Antibodies (56) and Unc-5 Homolog B (C. Elegans) Kits (5) and many more products for this protein.
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Disruption of the Unc5b or netrin-1a leads to aberrant extension of endothelial tip cell filopodia, excessive vessel branching and abnormal navigation
UNC5B-mediated signaling is a specific and autonomous component of fetal-placental angiogenesis.
Negative regulation of Naa10 (show ARD1A Proteins) towards NTN1 (show NTN1 Proteins) and its receptor UNC5B were also detected upon treatment of all-trans retinoid acid, which was often used to induce morphological differentiation.
fibronectin leucine-rich transmembrane protein 2 (FLRT2 (show FLRT2 Proteins)), a repulsive ligand of the UNC5 receptor family for neurons, is unexpectedly expressed in endothelial cells specifically in the placental labyrinth.
Blockade of Netrin-1 (show NTN1 Proteins)/Unc5b by monoclonal antibodies prevents bone destruction and reduces the severity of K/BxN serum transfer-induced arthritis
Data showed that albuminuria was significantly more pronounced in mice with proximal tubule specific deletion of UNC5B.
UNC5B receptor deletion exacerbates DSS (show PMP22 Proteins)-induced colitis in mice by increasing epithelial cell apoptosis.
unc5b expression is greater in adipose tissue of obese versus lean mice.
UNC5B plays a critical role in cell survival and kidney injury through Akt (show AKT1 Proteins)-mediated inactivation of p53 (show TP53 Proteins) in response to stress.
These studies demonstrate an important role for UNC5B during myocardial ischemia-reperfusion injury.
a significant role for UNC5B in the development of hepatic IRI and identified UNC5B as a potential drug target to prevent liver dysfunction in the future.
Robo4 (show ROBO4 Proteins) specifically binds to UNC5B, a vascular Netrin receptor, revealing unexpected interactions between two endothelial guidance receptors.
These findings point to a new important function of UNC5B and provide a potential basis for hASCs-mediated bone regeneration.
Our results suggest that UNC5B overexpression inhibits the proliferation and migration of bladder cancer cells by inducing cell cycle arrest at G2/M phase.
UNC5B expression is decreased in bladder cancer cells compared to normal bladder cell lines.
Data indicate that dysregulation of expression of netrin-1 NTN1 (show NTN1 Proteins) in smooth muscle cell (SMC (show DYM Proteins)) and its chemorepulsive receptor UNC5B in macrophages are involved in the development of atherosclerosis and unstable plaques.
unc5b expression is greater in adipose tissue of obese versus lean subjects.
Higher netrin-1 (show NTN1 Proteins) and lower UNC5B expression in all prostate carcinoma cell lines indicated that netrin-1 (show NTN1 Proteins) and UNC5B could be used to predict metastasis.
Low UNC5B expression was an independent risk factor for postoperative recurrence in patients with different stages and grades bladder cancer.
UNC5B protein expressed in macrophages in hypoxic regions of atherosclerotic regions in human.
UNC5B was downregulated in kidney carcinoma.
findings show that the netrin-1 (show NTN1 Proteins) and p53RDL1 system may regulate the induction of apoptosis in porcine granulosa cells
This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene.
netrin receptor UNC5B
, protein unc-5 homolog 2
, protein unc-5 homolog B
, unc-5 homolog 2
, unc5 homolog 2
, transmembrane receptor Unc5H2
, p53-regulated receptor for death and life protein 1
, unc-5 homolog C
, p53-regulated receptor for death and life
, unc-5 homolog B (C. elegans)
, UNC-5 receptor
, protein Xunc-5
, protein unc-5 homolog