Unc-5 Homolog B (C. Elegans) Proteins (UNC5B)

UNC5B encodes a member of the netrin family of receptors. Additionally we are shipping Unc-5 Homolog B (C. Elegans) Antibodies (56) and Unc-5 Homolog B (C. Elegans) Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UNC5B 107449 Q8K1S3
UNC5B 60630 O08722
UNC5B 219699 Q8IZJ1
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Top Unc-5 Homolog B (C. Elegans) Proteins at antibodies-online.com

Showing 9 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HEK-293 Cells Human Fc Tag   10 μg Log in to see 2 to 3 Days
Human Cells Human His tag,ECD 50 μg Log in to see 14 to 16 Days
HEK-293 Cells Human Fc Tag   50 μg Log in to see 5 to 8 Days
Human Cells Rat Fc Tag 100 μg Log in to see 14 to 16 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days

UNC5B Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus) ,
Human , , ,
, , , , , ,

More Proteins for Unc-5 Homolog B (C. Elegans) (UNC5B) Interaction Partners

Zebrafish Unc-5 Homolog B (C. Elegans) (UNC5B) interaction partners

  1. Disruption of the Unc5b or netrin-1a leads to aberrant extension of endothelial tip cell filopodia, excessive vessel branching and abnormal navigation

  2. A role of axon guidance genes in embryonic hindbrain patterning.

  3. UNC5B-mediated signaling is a specific and autonomous component of fetal-placental angiogenesis.

Human Unc-5 Homolog B (C. Elegans) (UNC5B) interaction partners

  1. Negative regulation of Naa10 towards NTN1 and its receptor UNC5B were also detected upon treatment of all-trans retinoid acid, which was often used to induce morphological differentiation.

  2. These findings point to a new important function of UNC5B and provide a potential basis for hASCs-mediated bone regeneration.

  3. Our results suggest that UNC5B overexpression inhibits the proliferation and migration of bladder cancer cells by inducing cell cycle arrest at G2/M phase.

  4. UNC5B expression is decreased in bladder cancer cells compared to normal bladder cell lines.

  5. Data indicate that dysregulation of expression of netrin-1 NTN1 in smooth muscle cell (SMC) and its chemorepulsive receptor UNC5B in macrophages are involved in the development of atherosclerosis and unstable plaques.

  6. unc5b expression is greater in adipose tissue of obese versus lean subjects.

  7. Higher netrin-1 and lower UNC5B expression in all prostate carcinoma cell lines indicated that netrin-1 and UNC5B could be used to predict metastasis.

  8. Low UNC5B expression was an independent risk factor for postoperative recurrence in patients with different stages and grades bladder cancer.

  9. UNC5B protein expressed in macrophages in hypoxic regions of atherosclerotic regions in human.

  10. UNC5B was downregulated in kidney carcinoma.

  11. Reducing Unc5b levels in Sip1 knockout slices and brains rescues cell migration in cortical interneurons.

  12. Hypoxia-inducible factor 1 controls the expression of the uncoordinated-5-B receptor, but not of netrin-1, in first trimester human placenta

  13. The mRNA expression analysis using tissue samples revealed that UNC5B mRNA was down-expressed in about 20% of CRC patients, and the patients with low-UNC5B-expression tumors showed a significantly higher recurrence rate after curative surgery.

  14. Netrin-1 can promote the potential of proliferation and invasion of extravillous trophoblasts in vitro through its receptors neogenin and UNC5B.

  15. Robo4 specifically binds to UNC5B, a vascular Netrin receptor, revealing unexpected interactions between two endothelial guidance receptors.

  16. The recruitment of PP2A to UNC5H2/B allows the activation of DAPk via a PP2A-mediated dephosphorylation and that this mechanism is involved in angiogenesis regulation.

  17. Down-regulation of UNC5b gene expression is related to angiogenesis of hepatocellular carcinoma.

  18. UNC5B receptor is localized to villous and extravillous cytotrophoblasts proximal to anchoring areas during the first trimester.

  19. Modulation of G(ialpha(2)) signaling by the axonal guidance of this protein

  20. may represent tumor suppressor that inhibit tumor extension outside the region of netrin-1 availability by inducing apoptosis

Pig (Porcine) Unc-5 Homolog B (C. Elegans) (UNC5B) interaction partners

  1. findings show that the netrin-1 and p53RDL1 system may regulate the induction of apoptosis in porcine granulosa cells

Unc-5 Homolog B (C. Elegans) (UNC5B) Protein Profile

Protein Summary

This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene.

Gene names and symbols associated with UNC5B

  • unc-5 netrin receptor B (unc5b)
  • unc-5 netrin receptor B (Unc5b)
  • unc-5 netrin receptor B (UNC5B)
  • unc-5 netrin receptor B L homeolog (unc5b.L)
  • 6330415E02Rik protein
  • A630020F16 protein
  • D10Bwg0792e protein
  • p53rdl1 protein
  • UNC5B protein
  • UNC5C protein
  • UNC5H2 protein

Protein level used designations for UNC5B

netrin receptor UNC5B , protein unc-5 homolog 2 , protein unc-5 homolog B , unc-5 homolog 2 , unc5 homolog 2 , UNC5H2 , transmembrane receptor Unc5H2 , p53-regulated receptor for death and life protein 1 , unc-5 homolog C , p53-regulated receptor for death and life , unc-5 homolog B (C. elegans) , UNC-5 receptor , protein Xunc-5 , protein unc-5 homolog

494130 Danio rerio
107449 Mus musculus
423716 Gallus gallus
60630 Rattus norvegicus
219699 Homo sapiens
524942 Bos taurus
733600 Sus scrofa
479239 Canis lupus familiaris
715786 Macaca mulatta
100072764 Equus caballus
398393 Xenopus laevis
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