anti-Vaccinia Related Kinase 1 (VRK1) Antibodies

Caenorhabditis elegans (C. elegans) Vaccinia Related Kinase 1 (VRK1) interaction partners

1. vrk-1 has a role in early uterine development in Caenorhabditis elegans

2. By coordinating VRK-1- and PP2A-mediated signaling on BAF, Lem4 and LEM-4L (Y55F3BR.8) controls postmitotic nuclear envelope formation in a function conserved from worms to humans.

3. Genome-wide analysis of germ cell proliferation in C. elegans identifies vrk-1 as a key regulator of cep-1/p53 (show TP53 Antibodies).

4. Data show that expression of the fibroblast growth factor-like protein EGL-17 and its receptor EGL-15 is reduced in vrk-1 mutants, suggesting that VRK-1 might act at least partially through activation of FGF signaling.

Human Vaccinia Related Kinase 1 (VRK1) interaction partners

1. this study not only provides a resource for investigating the unidentified functions of VRK1/VRK3, but also an insight into the regulatory roles of VRK1/VRK3 in biological processes.

2. Block the activation of the VRK1 promoter by Sox2 (show SOX2 Antibodies).

3. VRK1 and BANF1 (show BANF1 Antibodies) yielded AUCs of 0.790 and 0.735, respectively.

4. VRK1 AND VRK2 (show VRK2 Antibodies) expression are predictive of tumor response to neoadjuvant chemoradiation therapy in rectal adenocarcinoma.

5. VRK1 was lowly expressed in adherent MM cells and highly expressed in suspended cells. In addition, VRK1 was positively correlated with the proliferation of MM cells by regulating the expression of cell cycle-related protein, such as cyclinD1, CDK2 (show CDK2 Antibodies) and p27(kip1 (show CDKN1B Antibodies)).

6. we conclude that VRK1 may be a candidate prognostic biomarker as well as a potential therapeutical target of hepatocellular carcinoma

7. VRK1 may act as a tumor promoter by controlling the level of cell cycle regulators associated with G1/S transition and could potentially serve as a therapeutic target and/or prognostic biomarker for HCC (show FAM126A Antibodies).

8. VRK1 is a novel regulator of CBs (show CBS Antibodies) dynamics and stability in cell cycle by protecting coilin (show COIL Antibodies) from ubiquitination and degradation in the proteasome, and propose a model of CB dynamics.

9. VRK1 regulation of NBS1 (show NBN Antibodies) contributes to the stability of the repair complex and permits the sequential steps in DNA damage response.

10. VRK1 is a novel chromatin component that reacts to its alterations and participates very early in DNA damage response, functioning by itself or in cooperation with Ataxia Telangiectasia Mutated (show ATM Antibodies) Proteins.

Mouse (Murine) Vaccinia Related Kinase 1 (VRK1) interaction partners

1. VRK1 self-represses its activity to phosphorylate PXR (show NR1I2 Antibodies) through cyclin-dependent kinase 2 (CDK2 (show CDK2 Antibodies)) in high glucose conditions, resulting in the repression of the PCK1 (show PCK1 Antibodies) gene. This PXR (show NR1I2 Antibodies) phosphorylation was also observed in fasting mouse livers. Thus, the VRK1-CDK2 (show CDK2 Antibodies)-PXR (show NR1I2 Antibodies)-PP2Calpha (show PPM1A Antibodies)-SGK2 (show SGK2 Antibodies) pathway can be a novel physiological cell signaling that regulates gluconeogenesis in response to glucose.

2. VRK1 deficiency in human and mouse leads to downregulation of amyloid-beta precursor protein (APP (show APP Antibodies)). APP (show APP Antibodies) overexpression rescues the phenotype caused by Vrk1 knockdown, suggesting that VRK1 affects neuronal migration through an APP (show APP Antibodies)-dependent mechanism.

3. Data suggest that VRK1 is required for both follicle development and oocyte growth in mammalian female reproduction system.

4. Protein kinase (show CDK7 Antibodies) Cdelta regulates phosphorylation and down-regulation of Vaccinia-related kinase 1 (VRK1), thereby contributing to cell cycle arrest and apoptotic cell death in a p53 (show TP53 Antibodies)-dependent manner.

5. reduction of VRK1 activity causes a delay in meiotic progression during oogenesis

6. VRK1 is required for the proliferation and differentiation of undifferentiated spermatogonia, which are essential for spermatogenic cell maintenance

7. Depletion of VRK1 leads to progressive male infertility as a result of a cessation of spermatogonial proliferation.

8. These findings collectively support a role of VRK1 as a novel mitotic histone H3 (show HIST3H3 Antibodies) kinase in mammals.