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Required for organelle biogenesis, protein secretion, and development.
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It has been concluded that VMP1-mediated autophagy cooperated with Kras to promote pancreatic ductal adenocarcinoma initiation.
VMP1 modulates SERCA2 (show ATP2A2 Antibodies) activity to control endoplasmic reticulum contacts for autophagosome formation.
AKT1 (show AKT1 Antibodies)-GLI3 (show GLI3 Antibodies)-VMP1 pathway mediates KRAS oncogene (show RAB1A Antibodies)-induced autophagy in cancer cells.
Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death.
We hypothesize that in autophagy VMP1 is required for the correct morphogenesis of the omegasome by regulating MCS (show SMCP Antibodies) at the site of autophagosome formation.
expression of TMEM49 seems to be associated with the apoptosis and metastasis up signaling pathways of ovarian cancer, and suppression of its expression can inhibit cancer cell growth and metastasis
Study indicated that the expression of VMP1 was down-regulated and negatively correlated to the prognosis of colorectal cancer.
In colorectal cancer cells, VMP1-dependent autophagy appears to be pro-survival rather than pro-cell death.
in patients with invasive ductal carcinoma of the breast, Vmp1 expression had significant influence on disease-free survival time, with Vmp1-negative patients showing poor prognosis
These results underscore a novel role for VMP1 as a potential therapeutic target for combinatorial therapies aimed at sensitizing pancreatic cancer cells to chemotherapeutic agents
The VMP1-Beclin 1 (show BECN1 Antibodies) interaction regulates autophagy induction.
upregulation of Vmp1 was associated with suppression of growth and pulmonary metastases of HCC (show FAM126A Antibodies).
Required for organelle biogenesis, protein secretion, and development. Required for maintaining integrity of the endoplasmic reticulum. May play a role in autophagy.
NF-E2 induceble protein-2
, NF-E2-inducible protein 2
, protein ni-2
, transmembrane protein 49
, ectopic P-granules autophagy protein 3 homolog
, transport and golgi organization 5 homolog
, vacuole membrane protein 1
, transmembrane protein
, Transmembrane protein 49