Vpx Protein Proteins

Plays a role in nuclear translocation of the viral pre- integration complex (PIC), thus is required for the virus to infect non-dividing cells.

Data Quality
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Type
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    Protein
Antigen
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Reactivity
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  • 1
Application
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Host
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Binding Specificity
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Conjugate
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Protein Type
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Format
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3 Products
Recombinant Protein, Escherichia coli (E. coli) (Source), Purity > 90 %
ReactivitySimian Immunodeficiency Virus (SIV)
Application SDS
Order details Cat. No. ABIN5710812
$834.90
Plus shipping costs $45.00
Will be delivered in 11 Business Days
Recombinant Protein, Escherichia coli (E. coli) (Source), Purity > 90 %
ReactivitySimian Immunodeficiency Virus (SIV)
Application SDS
Order details Cat. No. ABIN5710778
$834.90
Plus shipping costs $45.00
Will be delivered in 11 Business Days
Recombinant Protein, Escherichia coli (E. coli) (Source), Purity > 90 %
ReactivityHuman Immunodeficiency Virus (HIV)
Application SDS
Order details Cat. No. ABIN5710828
$834.90
Plus shipping costs $45.00
Will be delivered in 11 Business Days
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Vpx Protein (VPX) Protein Profile

Protein Summary

Plays a role in nuclear translocation of the viral pre- integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription (By similarity). {ECO:0000250}.

Gene names and symbols associated with Vpx Protein Proteins (VPX)

  • vpx protein (vpx) antibody

Protein level used designations for Vpx Protein Proteins (VPX)

Viral protein X , X ORF protein

GENE ID SPECIES
1490006 Simian immunodeficiency virus
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