Vpx Protein (VPX) (AA 1-113), (full length) protein (His tag)
VPX
Origin: Human Immunodeficiency Virus (HIV)
Host: Escherichia coli (E. coli)
Recombinant
> 90 %
SDS
1 image
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- Target See all Vpx Protein (VPX) Proteins
- Vpx Protein (VPX)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-113, full length
- Origin
- Human Immunodeficiency Virus (HIV)
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- His tag
- Application
- SDS-PAGE (SDS)
- Sequence
- MTDPRERVPP GNSGEETIGE AFEWLERTIE ALNREAVNHL PRELIFQVWQ RSWRYWHDEQ GMSASYTKYR YLCLMQKAIF THFKRGCTCW GEDMGREGLE DQGPPPPPPP GLV
- Purification
- SDS-PAGE
- Purity
- > 90 %
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Vpx Protein (VPX) (AA 1-112), (full length) protein (His-SUMO Tag)
VPX Origin: Simian Immunodeficiency Virus (SIV) Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- Vpx Protein (VPX)
- Alternative Name
- VPX (VPX Products)
- Synonyms
- vpx protein Protein, vpx Protein
- Target Type
- Viral Protein
- Background
- Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.
- Molecular Weight
- 17.3 kDa
- UniProt
- P18099
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