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WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. Additionally we are shipping WWOX Antibodies (98) and WWOX Kits (7) and many more products for this protein.
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the ability of WWOX to facilitate escape from mitochondrial damage-induced glycolysis (Warburg effect) is, therefore, a plausible mechanism for its tumor suppressor activity.
Together these results provide a molecular basis for the tumor suppressor functions of WWOX and the better prognosis observed in cancer patients with higher levels of WWOX activity.
Aberrant WWOX expression contributes to the altered metabolism in cancer.
study finds significant proportion of Wwox interactors have roles in aerobic metabolism; Wwox contributes to pathways involving aerobic metabolism and oxidative stress, providing an explanation for the 'non-classical tumour suppressor' behaviour of WWOX
the Drosophila orthologue of the human WWOX gene was identified. the protective function of DmWWOX in response to irradiation in Drosophila is conserved with human WWOX
data show that the chromosomal location of WWOX is conserved between man and 4 major domesticated species. Moreover, the annotation of the bovine gene also suggests a highly conserved genomic arrangement, including number and size of introns
A model is supported in which FRA16D common fragile sites are sequences that may initiate replication in early-mid S phase but are slow to complete replication, and the chromosomal breaks and gaps observed in metaphase cells result from unreplicated DNA.
Data conclude that WWOX sensitises EOC to paclitaxel via ER stress-induced apoptosis, and predicts clinical outcome in patients. Thus, ER stress response mechanisms could be targeted to overcome chemoresistance in cancer.
Data show that patients with advanced-stage oral cancer were associated with a higher frequency of WWOX rs11545028 polymorphisms with the variant genotype TT than did patients with the wild-type gene.
WWOX expression was strongly inhibited in human lung cancers and lung cancer cell lines. Reintroducing WWOX into lung cancer cells inhibited their invasive phenotype through downregulating RUNX2 (show RUNX2 Proteins) and its target genes including MMP-9 (show MMP9 Proteins) expression.
Our data suggests that the deletion genotypes of CNV-67048 in WWOX predispose their carriers to intracranial aneurysms
It has been proposed that Fhit and Wwox loss work synergistically in cancer progression and that DNA damage caused by Fhit could be targeted early in cancer initiation for prevention, while DNA damage caused by Wwox loss could be targeted later in cancer progression, particularly in cancers that develop resistance to genotoxic therapies. (Review)
genetic variations in WWOX may be a significant predictor of early HCC (show FAM126A Proteins) occurrence and a reliable biomarker for disease progression
a WWOX-p53 (show TP53 Proteins) network regulates normal bone formation and that disruption of this network in osteoprogenitors results in accelerated osteosarcoma.
Low WWOX expression is associated with Head and Neck Squamous Cell Carcinoma.
Knockdown of lung WWOX expression in mice was observed to cause neutrophil influx and was accompanied by a corresponding vascular leak and inflammatory cytokine production. In cultured human alveolar epithelial cells, loss of WWOX expression resulted in increased c-Jun (show JUN Proteins)- and IL-8 (show IL8 Proteins)-dependent neutrophil chemotaxis toward cell monolayers.
Brca1 (show BRCA1 Proteins)-Wwox interaction supports non-homologous end-joining as the dominant DSB repair pathway in Wwox-sufficient cells
Both Wwox null and Wwoxhep-/- mice demonstrated reductions in ApoA-I (show APOA1 Proteins) and Abca1 (show ABCA1 Proteins) levels, critical components in reverse cholesterol transport and generation of nascent HDL (show HSD11B1 Proteins) particles.
WWOX plays a critical role in normal central nervous system development and disease.
WWOX has many functions, and its deletion affects cellular metabolism and neoplastic progression.
Wwox-deficient mice develop normally but succumb to a lethal hypoglycemia early in life. WWOX as a tumor suppressor with emerging role in regulation of aerobic glycolysis.
These findings identify a novel role for the tumor suppressor WWOX and show that loss of WWOX expression may drive genomic instability
Modeling WWOX inactivation revealed a complex phenotype including postnatal lethality, defects in bone metabolism and steroidogenesis and tumor suppressor function resulting in osteosarcomas.
WWOX ablation leads to impaired mammary ductal growth. Moreover, targeted deletion of WWOX is associated with increased levels of fibronectin (show FN1 Proteins), a component of the extracellular matrix.
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.
, WW domain-containing oxidoreductase
, retinol dehydrogenase 12
, WW domain containing oxidoreductase
, WW domain-containing protein WWOX
, fragile site FRA16D oxidoreductase
, short chain dehydrogenase/reductase family 41C, member 1
, WW-domain oxidoreductase