WW Domain Containing Oxidoreductase Proteins (WWOX)

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.

• WW domain containing oxidoreductase (Wwox)
• WW domain-containing oxidoreductase (LOC411815)
• WW domain containing oxidoreductase (WWOX)
• WW domain-containing oxidoreductase (CpipJ_CPIJ004939)
• WW domain-containing oxidoreductase (MCYG_01584)
• Show all gene names
• WW domain-containing oxidoreductase (VDBG_05631)
• WW domain-containing oxidoreductase (VDBG_01326)
• WW domain-containing oxidoreductase (VDBG_06753)
• WW domain-containing oxidoreductase (Tsp_03967)
• WW domain-containing oxidoreductase (LOC100284583)
• WW domain containing oxidoreductase (wwox)
• WW domain-containing oxidoreductase (Wwox)

• 5330426P09Rik protein
• 9030416C10Rik protein
• anon-EST:Posey177 protein
• CG7221 protein
• D16S432E protein
• Show all synonym aliases
• Dmel\\CG7221 protein
• DmWWOX protein
• FOR protein
• FRA16D protein
• GB11795 protein
• HHCMA56 protein
• PRO0128 protein
• SDR41C1 protein
• WOX1 protein
• WWOX protein
• zgc:55975 protein

CG7221-PA , Wwox-PA , WW domain-containing oxidoreductase , retinol dehydrogenase 12 , WW domain containing oxidoreductase , WW domain-containing protein WWOX , fragile site FRA16D oxidoreductase , short chain dehydrogenase/reductase family 41C, member 1 , WW-domain oxidoreductase