WW Domain Containing Oxidoreductase Proteins (WWOX)

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. Additionally we are shipping WWOX Antibodies (98) and WWOX Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
WWOX 51741 Q9NZC7
Mouse WWOX WWOX 80707 Q91WL8
Rat WWOX WWOX 292041  
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Top WWOX Proteins at antibodies-online.com

Showing 9 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
Details
Escherichia coli (E. coli) Human His tag 50 μg Log in to see 15 to 19 Days
$400.00
Details
Yeast Zebrafish His tag   1 mg Log in to see 60 to 71 Days
$3,144.17
Details
Yeast Chicken His tag   1 mg Log in to see 60 to 71 Days
$3,151.50
Details
Yeast Orang-Utan His tag   1 mg Log in to see 60 to 71 Days
$3,151.50
Details
Escherichia coli (E. coli) Human His tag   1 mg Log in to see 2 to 3 Days
$5,723.08
Details
Human Un-conjugated   10 μg Log in to see 6 to 8 Days
$256.30
Details

WWOX Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,

More Proteins for WW Domain Containing Oxidoreductase (WWOX) Interaction Partners

Fruit Fly (Drosophila melanogaster) WW Domain Containing Oxidoreductase (WWOX) interaction partners

  1. the ability of WWOX to facilitate escape from mitochondrial damage-induced glycolysis (Warburg effect) is, therefore, a plausible mechanism for its tumor suppressor activity.

  2. Together these results provide a molecular basis for the tumor suppressor functions of WWOX and the better prognosis observed in cancer patients with higher levels of WWOX activity.

  3. Aberrant WWOX expression contributes to the altered metabolism in cancer.

  4. study finds significant proportion of Wwox interactors have roles in aerobic metabolism; Wwox contributes to pathways involving aerobic metabolism and oxidative stress, providing an explanation for the 'non-classical tumour suppressor' behaviour of WWOX

  5. the Drosophila orthologue of the human WWOX gene was identified. the protective function of DmWWOX in response to irradiation in Drosophila is conserved with human WWOX

Cow (Bovine) WW Domain Containing Oxidoreductase (WWOX) interaction partners

  1. data show that the chromosomal location of WWOX is conserved between man and 4 major domesticated species. Moreover, the annotation of the bovine gene also suggests a highly conserved genomic arrangement, including number and size of introns

Human WW Domain Containing Oxidoreductase (WWOX) interaction partners

  1. A model is supported in which FRA16D common fragile sites are sequences that may initiate replication in early-mid S phase but are slow to complete replication, and the chromosomal breaks and gaps observed in metaphase cells result from unreplicated DNA.

  2. Data conclude that WWOX sensitises EOC to paclitaxel via ER stress-induced apoptosis, and predicts clinical outcome in patients. Thus, ER stress response mechanisms could be targeted to overcome chemoresistance in cancer.

  3. Data show that patients with advanced-stage oral cancer were associated with a higher frequency of WWOX rs11545028 polymorphisms with the variant genotype TT than did patients with the wild-type gene.

  4. WWOX expression was strongly inhibited in human lung cancers and lung cancer cell lines. Reintroducing WWOX into lung cancer cells inhibited their invasive phenotype through downregulating RUNX2 (show RUNX2 Proteins) and its target genes including MMP-9 (show MMP9 Proteins) expression.

  5. Our data suggests that the deletion genotypes of CNV-67048 in WWOX predispose their carriers to intracranial aneurysms

  6. It has been proposed that Fhit and Wwox loss work synergistically in cancer progression and that DNA damage caused by Fhit could be targeted early in cancer initiation for prevention, while DNA damage caused by Wwox loss could be targeted later in cancer progression, particularly in cancers that develop resistance to genotoxic therapies. (Review)

  7. genetic variations in WWOX may be a significant predictor of early HCC (show FAM126A Proteins) occurrence and a reliable biomarker for disease progression

  8. a WWOX-p53 (show TP53 Proteins) network regulates normal bone formation and that disruption of this network in osteoprogenitors results in accelerated osteosarcoma.

  9. Low WWOX expression is associated with Head and Neck Squamous Cell Carcinoma.

  10. Knockdown of lung WWOX expression in mice was observed to cause neutrophil influx and was accompanied by a corresponding vascular leak and inflammatory cytokine production. In cultured human alveolar epithelial cells, loss of WWOX expression resulted in increased c-Jun (show JUN Proteins)- and IL-8 (show IL8 Proteins)-dependent neutrophil chemotaxis toward cell monolayers.

Mouse (Murine) WW Domain Containing Oxidoreductase (WWOX) interaction partners

  1. Knockdown of lung WWOX expression in mice was observed to cause neutrophil influx and was accompanied by a corresponding vascular leak and inflammatory cytokine production. In cultured human alveolar epithelial cells, loss of WWOX expression resulted in increased c-Jun (show JUN Proteins)- and IL-8 (show IL8 Proteins)-dependent neutrophil chemotaxis toward cell monolayers.

  2. Brca1 (show BRCA1 Proteins)-Wwox interaction supports non-homologous end-joining as the dominant DSB repair pathway in Wwox-sufficient cells

  3. Both Wwox null and Wwoxhep-/- mice demonstrated reductions in ApoA-I (show APOA1 Proteins) and Abca1 (show ABCA1 Proteins) levels, critical components in reverse cholesterol transport and generation of nascent HDL (show HSD11B1 Proteins) particles.

  4. Aberrant WWOX expression contributes to the altered metabolism in cancer.

  5. WWOX plays a critical role in normal central nervous system development and disease.

  6. WWOX has many functions, and its deletion affects cellular metabolism and neoplastic progression.

  7. Wwox-deficient mice develop normally but succumb to a lethal hypoglycemia early in life. WWOX as a tumor suppressor with emerging role in regulation of aerobic glycolysis.

  8. These findings identify a novel role for the tumor suppressor WWOX and show that loss of WWOX expression may drive genomic instability

  9. Modeling WWOX inactivation revealed a complex phenotype including postnatal lethality, defects in bone metabolism and steroidogenesis and tumor suppressor function resulting in osteosarcomas.

  10. WWOX ablation leads to impaired mammary ductal growth. Moreover, targeted deletion of WWOX is associated with increased levels of fibronectin (show FN1 Proteins), a component of the extracellular matrix.

WWOX Protein Profile

Protein Summary

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.

Gene names and symbols associated with WWOX

  • WW domain containing oxidoreductase (Wwox)
  • WW domain-containing oxidoreductase (LOC411815)
  • WW domain containing oxidoreductase (WWOX)
  • WW domain-containing oxidoreductase (CpipJ_CPIJ004939)
  • WW domain-containing oxidoreductase (MCYG_01584)
  • WW domain-containing oxidoreductase (VDBG_05631)
  • WW domain-containing oxidoreductase (VDBG_01326)
  • WW domain-containing oxidoreductase (VDBG_06753)
  • WW domain-containing oxidoreductase (Tsp_03967)
  • WW domain-containing oxidoreductase (LOC100284583)
  • WW domain containing oxidoreductase (wwox)
  • WW domain-containing oxidoreductase (Wwox)
  • 5330426P09Rik protein
  • 9030416C10Rik protein
  • anon-EST:Posey177 protein
  • CG7221 protein
  • D16S432E protein
  • Dmel\\CG7221 protein
  • DmWWOX protein
  • FOR protein
  • FRA16D protein
  • GB11795 protein
  • HHCMA56 protein
  • PRO0128 protein
  • SDR41C1 protein
  • WOX1 protein
  • WWOX protein
  • zgc:55975 protein

Protein level used designations for WWOX

CG7221-PA , Wwox-PA , WW domain-containing oxidoreductase , retinol dehydrogenase 12 , WW domain containing oxidoreductase , WW domain-containing protein WWOX , fragile site FRA16D oxidoreductase , short chain dehydrogenase/reductase family 41C, member 1 , WW-domain oxidoreductase

GENE ID SPECIES
34090 Drosophila melanogaster
411815 Apis mellifera
610120 Canis lupus familiaris
618792 Bos taurus
715635 Macaca mulatta
737907 Pan troglodytes
6036407 Culex quinquefasciatus
9230790 Arthroderma otae CBS 113480
9531509 Verticillium alfalfae VaMs.102
9536255 Verticillium alfalfae VaMs.102
9537317 Verticillium alfalfae VaMs.102
10904221 Trichinella spiralis
100229880 Taeniopygia guttata
100284583 Zea mays
51741 Homo sapiens
415801 Gallus gallus
100172779 Pongo abelii
393887 Danio rerio
80707 Mus musculus
292041 Rattus norvegicus
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