anti-alpha Hemoglobin Stabilizing Protein (aHSP) Antibodies

Act as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Additionally we are shipping aHSP Proteins (16) and aHSP Kits (15) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
aHSP 51327 Q9NZD4
aHSP 170812 Q9CY02
aHSP 293522  
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Top anti-aHSP Antibodies at antibodies-online.com

Showing 10 out of 60 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Mouse Rabbit Un-conjugated FM, IHC (fp), ELISA, WB Immunohistochemistry of Rabbit anti-AHSP antibody. Tissue: A. Normal bone marrow, H&E. B. CD235a stains both nucleated EPs and mature, anucleate RBCs. C. AHSP stains nucleated EPs, but not mature, anucleate RBCs. D. CD71 stains nucleated EPs, but not mature, anucleate RBCs. Fixation: acetic acid-zinc-formalin and formalin fixation, embedded in paraffin Antigen retrieval: TRIS-EDTA pH9.0 Primary antibody: AHSP antibody at 1:8,000 for overnight at 4°C Secondary antibody: anti-rabbit secondary at (1:10,000 for 45 min at RT) Localization: Anti-AHSP is cytoplasmic Staining: AHSP antibody as precipitated brown signal with a purple nuclear counterstain using Bond-max™ – fully automated for IHC. 100 μL 5 to 7 Days
$598.50
Details
Rat Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Rat Liver Tissue; Lane2: Mouse Liver Tissue. 100 μg 13 to 16 Days
$342.00
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Used in DAB staining on fromalin fixed paraffin- embedded stomach tissue 100 μg 15 to 18 Days
$324.00
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB 100 μL 11 to 14 Days
$639.83
Details
Human Rabbit Un-conjugated ICC, IHC, WB Western Blot; Sample: Rat Liver lysate; Primary Ab: 1µg/ml Rabbit Anti-Human aHSP Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) 100 μg 15 to 18 Days
$316.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of AHSP expression in mouse liver (A), rat liver (B) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Rat Rabbit Un-conjugated IF/ICC, IHC, IP, WB Western blot analysis of (1) Rat Liver Tissue and (2) Mouse Liver Tissue. Western blot analysis of recombinant Rat aHSP. 100 μg 11 to 18 Days
$440.62
Details
Mouse Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using AHSP antibody (ABIN5973863) at 1/1000 dilution. 100 μL 11 to 16 Days
$426.40
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged ERAF is 0.03 ng/ml as a capture antibody. Western Blot detection against Immunogen (36.96 KDa) . 100 μg 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various tissues, using AHSP antibody. 100 μL 11 to 13 Days
$366.77
Details

Top referenced anti-aHSP Antibodies

  1. Human Monoclonal aHSP Primary Antibody for ELISA, WB - ABIN526641 : Wang, Fang, Guo, Ren, Zhang: Transgenic human alpha-hemoglobin stabilizing protein could partially relieve betaIVS-2-654-thalassemia syndrome in model mice. in Human gene therapy 2010 (PubMed)

  2. Mouse (Murine) Polyclonal aHSP Primary Antibody for FM, IHC (fp) - ABIN1043695 : Nasimuzzaman, Khandros, Wang, Kong, Zhao, Weiss, Rivella, Weiss, Persons: Analysis of alpha hemoglobin stabilizing protein overexpression in murine β-thalassemia. in American journal of hematology 2010 (PubMed)

More Antibodies against aHSP Interaction Partners

Human alpha Hemoglobin Stabilizing Protein (aHSP) interaction partners

  1. The study documents that among the HbE beta thalassemia patients with varying severity, an exon mutation in AHSP is significantly prevalent only among the transfusion-dependent beta-thalassemia patients.

  2. In the presence of free alpha subunits and H2O2, both HbA and HbE showed bCys93 oxidation which increased with higher H2O2 concentrations. In the presence of Alpha-hemoglobin stabilizing protein (AHSP)Cys93 oxidation was substantially reduced in both proteins.in the presence of excess free alpha-subunit and under the same oxidative conditions, these events are substantially increased for HbE compared to HbA

  3. Findings indicate that alpha-hemoglobin-stabilizing protein (AHSP) expression is a biomarker of hemoglobin H (HbH) disease severity and infer an important role of AHSP in modulating the pathophysiology of this disease.

  4. AHSP is predominantly expressed in erythroid precursors in bone marrow biopsy specimens from patients with hematologic malignancies.

  5. AHSP expression was higher in patients with sickle cell anemia versus thalassemia, with no significant difference between BTM and BTI. Expression was higher in patients with NTDT and on hydroxyurea therapy.

  6. In maturing RBC progenitors AHSP bind to free alpha-globin chains to increase the HbA production. (Review)

  7. analysis showed binding of STAT3 to AHSP promoter and binding was significantly augmented with IL6 stimulation and upon alpha-globin overexpression

  8. The relationship between AHSP gene expression, disease severity, and the beta/alpha globin mRNA ratio was studied among different homozygote beta-thalassemia patients.

  9. alpha-Hemoglobin-stabilizing protein (AHSP) perturbs the proximal heme pocket of oxy-alpha-hemoglobin and weakens the iron-oxygen bond.

  10. alpha-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of alpha-subunits of human HbA with hydrogen peroxide.

  11. AHSP acts as a molecular chaperone by rapidly binding and stabilizing met-alpha hemichrome folding intermediates

  12. AHSP could be a secondary compensatory mechanism in red blood cells to counterbalance the excess of alpha-globin chains in HbE/beta-thalassaemia individuals.

  13. NF-E2 may play an important role in AHSP gene regulation, providing new insights into the molecular mechanisms underlying the erythroid-specific expression of AHSP as well as new possibilities for beta-thalassemia treatment

  14. No significant association has been found between specific AHSP alleles or haplotypes and the disease severity of beta-thalassemia. Our study suggested that AHSP is not a significant genetic modifier of beta-thalassemia in southern China.

  15. Overexpression of human AHSP & 2 mutant versions with AA substitutions confering 3- or 13-fold higher affinity for alpha-globin had no major effects on hematologic parameters in beta-thalassemic mice.

  16. analysis of the action of a human mutant, AHSPV56G, of alpha-hemoglobin stabilizing protein (AHSP)

  17. Studies indicate that the interaction of alpha-Hb with AHSP involves surfaces normally employed in binding to beta-Hb.

  18. Different mechanisms may be responsible for the amount of abnormal Hb recovered, such as a highly unstable alpha chain or an impaired formation of the complex AHSP/alpha-Hb or a modification of the alphabeta dimer formation.

  19. An abundant erythroid protein that stabilizes free alpha-haemoglobin.

  20. determination as a predominantly alpha-helical globular protein with a somewhat asymmetric shape

Mouse (Murine) alpha Hemoglobin Stabilizing Protein (aHSP) interaction partners

  1. eNOS reduced AHSP-bound alpha-globin approximately 6-fold faster than did the major erythrocyte hemoglobin reductases (cytochrome B5 reductase plus cytochrome B5). Our data support a model whereby redox-sensitive shuttling of EC alpha-globin between AHSP and eNOS regulates EC NO degradation and vascular tone.

  2. role of alpha-hemoglobin stabilizing protein in hemoglobin assembly

  3. Endogenous AHSP is not limiting for alpha-globin detoxification in beta-thalassemic mice.

  4. An abundant erythroid protein that stabilizes free alpha-haemoglobin.

  5. activin A does not appear to affect the exocrine or endocrine components of the pancreas, but promotes differentiation of pancreatic tissue into intestine via a Shh-dependent mechanism

  6. Loss of AHSP impairs erythropoiesis and exacerbates beta-thalassemia.

  7. These results support the hypothesis that EKLF acts as a transcription factor and a chromatin modulator for the AHSP and beta-globin genes and indicate that EKLF may play similar roles for other erythroid genes.

  8. developmental stage- and differentiation state-specific regulation of the nuclear transport of EKLF might be one of the steps necessary for the switch-on of the mammalian adult beta globin gene transcription

  9. AHSP also acts as a molecular chaperone to stabilize nascent alpha-globin for hemoglobin A assembly

  10. The expression of AHSP in a subclone of murine erythroleukemia cells in relationship to prion protein on the cell surface is reported.

aHSP Antigen Profile

Protein Summary

Act as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation (By similarity).

Gene names and symbols associated with aHSP

  • alpha hemoglobin stabilizing protein (AHSP) antibody
  • alpha hemoglobin stabilizing protein (Ahsp) antibody
  • alpha-hemoglobin-stabilizing protein-like (LOC100620111) antibody
  • AHSP antibody
  • EDRF antibody
  • Eraf antibody

Protein level used designations for aHSP

alpha hemoglobin stabilizing protein , erythroid associated factor , alpha hemoglobin stabilising protein , alpha-hemoglobin-stabilizing protein , erythroid differentiation associated factor , erythroid differentiation-related factor , erythroid-associated factor

GENE ID SPECIES
454073 Pan troglodytes
714392 Macaca mulatta
100127218 Ovis aries
100340962 Oryctolagus cuniculus
51327 Homo sapiens
170812 Mus musculus
338381 Bos taurus
293522 Rattus norvegicus
100712877 Cavia porcellus
100620111 Sus scrofa
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