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Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. Additionally we are shipping and many more products for this protein.
Showing 10 out of 145 products:
Cow (Bovine) Monoclonal CLTC Primary Antibody for ICC, FACS - ABIN152766
Fernandez, McVicker, Tuma, Tuma: Ethanol selectively impairs clathrin-mediated internalization in polarized hepatic cells. in Biochemical pharmacology 2009
Show all 6 Pubmed References
Cow (Bovine) Monoclonal CLTC Primary Antibody for WB - ABIN265878
Grossman, Ebke, Beight, Jang, Crabb, Hagstrom: Protein partners of dynamin-1 in the retina. in Visual neuroscience 2013
Human Polyclonal CLTC Primary Antibody for IF (p) - ABIN891159
Kuhn, Vanhecke, Michen, Blank, Gehr, Petri-Fink, Rothen-Rutishauser: Different endocytotic uptake mechanisms for nanoparticles in epithelial cells and macrophages. in Beilstein journal of nanotechnology 2014
miR (show MLXIP Antibodies)-579-3p controls melanoma progression and resistance to target therapy by targeting the 3'UTR (show UTS2R Antibodies) of two oncoproteins: BRAF (show BRAF Antibodies) and MDM2 (show MDM2 Antibodies).
Durable (>/=3 years) survival is achievable with dabrafenib plus trametinib in patients with BRAF (show BRAF Antibodies) V600-mutant metastatic melanoma
A high extent more than 25% of BRAF (show BRAF Antibodies)(V600E) alleles may be associated with disease outcome in PTC (show F9 Antibodies) patients.
Study found that high expression of LC3B (show MAP1LC3B Antibodies) protein was associated with the presence of BRAF (show BRAF Antibodies) V600E mutation and temporal lesion in glioneuronal tumors, as well as in gangliogliomas alone. As for Beclin-1 protein (show BECN1 Antibodies), it showed statistically significant correlation with BRAF (show BRAF Antibodies) V600E mutation in glioneuronal tumors.
We suggest that BRAF (show BRAF Antibodies) mutant patients should not be considered as having a unique biology and provide an in depth characterization of heterogeneous motifs that may be exploited for drug targeting.
The results establish a link between BRAF (show BRAF Antibodies)(V600E) and NOX4 (show NOX4 Antibodies), which is confirmed by a comparative analysis of NOX4 (show NOX4 Antibodies) expression in human (TCGA) and mouse thyroid cancers.
PD-L1 (show CD274 Antibodies) expression in colorectal cancer is associated with microsatellite instability and BRAF (show BRAF Antibodies) mutations.
Results indicate that MAPK (show MAPK1 Antibodies) pathway inhibition leads to changes in the immunological properties of mutant BRAF (show BRAF Antibodies) melanoma cells.
Results show that promoter mutations render telomerase reverse transcriptase (TERT (show TERT Antibodies)) expression dependent on MAPK (show MAPK1 Antibodies) signal pathway activation due to oncogenic BRAF (show BRAF Antibodies) or NRAS (show NRAS Antibodies) mutations.
Of these 6 patients, 3 had a BRAF (show BRAF Antibodies) mutation positive primary with a BRAF (show BRAF Antibodies) mutation negative metastatic lesion, while the other 3 had a BRAF (show BRAF Antibodies) mutation negative primary with BRAF (show BRAF Antibodies) mutation positive metastasis.There is an important discordance rate in the BRAF (show BRAF Antibodies) mutation status of melanoma primaries versus brain metastases.
The clathrin heavy chain CHC-1 negatively regulates pulling forces acting on centrosomes during interphase and on spindle poles during mitosis in one-cell C. elegans embryos.
Inactivating epn-1 (show EPN1 Antibodies) or chc-1 disrupts engulfment by impairing actin polymerization. CHC-1 is enriched on extending pseudopods together with EPN-1 (show EPN1 Antibodies), in an EPN-1 (show EPN1 Antibodies)-dependent manner.
These results indicate that a high level of CHC activity is required for receptor-mediated endocytosis in nonneuronal cells but is largely dispensable for maintenance of synaptic vesicle pools.
Loss of SNX-1 (show SNX1 Antibodies), RME-8, or the clathrin chaperone Hsc70 (show HSPA8 Antibodies)/HSP-1 leads to over-accumulation of endosomal clathrin, reduced clathrin dynamics, and missorting of MIG-14 (show RAE1 Antibodies) to the lysosome.
Taken together, these results demonstrate that Japanese encephalitis virus enters porcine kidney epithelial PK15 cells through cholesterol- and clathrin-mediated endocytosis.
Clathrin plays a crucial role in meiotic spindle function in maturing oocytes, possibly through spindle stabilization
three different clathrin-box motif peptides can each simultaneously bind not only to the previously characterized clathrin-box site but also to the W-box site and the beta-arrestin splice loop site on a single TD.
Structure of clathrin coat with bound Hsc70 (show HSPA8 Antibodies) and auxilin (show DNAJC6 Antibodies).
clathrin-FKBP36-Hsp72 complexes resulting from both identified interactions are bound to the matrices of clathrin-coated vesicles in spermatocytes, which indicates a possible role of FKBP36 and Hsp72 in the disassembly of clathrin coats
our results demonstrate that CKAP5 (show CKAP5 Antibodies) is important in oocyte maturation and early embryo development, and CKAP5 (show CKAP5 Antibodies) might work together with CLTC in mouse oocyte maturation
SP-A (show SFTPA1 Antibodies) transiently enhances the basal protein expression of CHC and alpha-adaptin (show AP2A2 Antibodies).
MiR (show MLXIP Antibodies)-199a-5p suppresses tumorigenesis by targeting CLTC in hepatocellular carcinoma.
PTEN-like domains of GAK and auxilin are not essential for Hsc70-dependent chaperoning and uncoating of clathrin, but depending on the tissue, these domains appear to increase the efficiency of these co-chaperones.
The clathrin-mediated endocytic machinery combines with Dab2 (show DAB2 Antibodies) to facilitate the endocytosis of RGD-integrin-beta3 clusters.
Taken together, these results show that CLTC plays an important role in spindle assembly and chromosome congression through a microtubule correlation mechanism during mouse oocyte maturation.
Auditory inner hair cells use dynamin-dependent endocytosis via clathrin-mediated endocytosis.
Data indicate that dynamin (show DNM1 Antibodies), clathrin, adaptor protein complex-2 (AP2 (show TFAP2A Antibodies)), and amphiphysin (show AMPH Antibodies) contribute to the depolarization-evoked entry in endocytosis.
This study reveals a novel functional role of clathrin-coated structure in GMR (show CSF2RA Antibodies) signaling and the oncogenesis of JAK2V617F.
The authors report that Dab2, previously described as an inhibitor of Wnt/beta-catenin signalling, selectively recruits LRP6 to the clathrin-dependent endocytic route, thereby sequestering it from caveolin-mediated endocytosis.
Data indicate that MTV1 (AT3G16270) and AGD5 (AT5G54310) Physically Interact with clathrin.
study presents a genetic characterization of the role of clathrin in endocytosis and auxin-mediated plant development; data demonstrate a fundamental role for clathrin function in cell polarity, growth, patterning, and organogenesis
Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.
94 kDa B-raf protein
, B-Raf proto-oncogene serine/threonine-protein kinase (p94)
, murine sarcoma viral (v-raf) oncogene homolog B1
, proto-oncogene B-Raf
, serine/threonine-protein kinase B-raf
, v-raf murine sarcoma viral oncogene homolog B1
, clathrin heavy chain
, Clathrin Heavy Chain family member (chc-1)
, clathrin heavy chain 1
, clathrin heavy-chain
, clathrin, heavy polypeptide (Hc)
, clathrin heavy chain on chromosome 17
, clathrin, heavy polypeptide-like 2
, clathrin, heavy chain (Hc)
, clathrin, heavy chain (Hc) L homeolog