anti-clathrin, Heavy Chain (Hc) (CLTC) Antibodies

Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CLTC 673 P15056
CLTC 67300 Q68FD5
CLTC 54241 P11442
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Top anti-clathrin, Heavy Chain (Hc) Antibodies at antibodies-online.com

Showing 10 out of 145 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Mouse Un-conjugated EIA, FACS, IF, IP, WB 0.1 mg Log in to see 6 to 8 Days
$313.50
Details
Cow Mouse Un-conjugated ICC, FACS, IF, IM, IHC (p), IP, IHC, WB Flow Cytometry: Clathrin Heavy Chain 1/CHC17 Antibody (X22) [ABIN152766] - Analysis of Alexa Fluor (R) 488 conjugate of ABIN152766. A cell surface stain was performed on HeLa cells with Clathrin Heavy Chain 1 antibody ABIN152766AF488 (blue) along with a matched isotype control NBP2-27287AF488 (orange). Cells were incubated in an a Western Blot: Clathrin Heavy Chain 1/CHC17 Antibody (X22) [ABIN152766] - Analysis of 25 ug of human brain lysates. 0.1 mL Log in to see 7 to 9 Days
$444.19
Details
Cow Mouse Un-conjugated WB Western Blot: Clathrin heavy chain Antibody (TD.1) [ABIN2658781] - Cell line lysates were separated on SDS-PAGE and probed with 4 ug/mL Monoclonal Anti-Clathrin Heavy Chain Clone: TD.1. The antibody was developed using Goat Anti-Mouse IgG-Peroxidase and a chemiluminescent substrate. Lanes 1. HEK-293T 2. HeLa 3. SH-SY5Y 4. SK-N-SH 5. COS7 6. PC12 7. Neuro-2a 0.1 mL Log in to see 7 to 9 Days
$444.19
Details
Arabidopsis thaliana Rabbit Un-conjugated IF, IL, WB 100 μg Log in to see 6 to 8 Days
$557.87
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB CLTC Antibody (Center) (ABIN652092) western blot analysis in Hela cell line lysates (35 µg/lane). This demonstrates the CLTC antibody detected the CLTC protein (arrow). CLTC antibody (Center) (ABIN652092) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Bat Goat Un-conjugated IHC (p) Adrenal, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Kidney, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7 to 9 Days
$484.00
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of Clathrin Heavy Chain staining in rat kidney formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incuba Western blot analysis of Clathrin Heavy Chain expression in Hela (A), MCF7 (B), mouse lung (C), rat brain (D) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Amphibian Mouse Un-conjugated IHC (fro), WB   0.1 mg Log in to see 6 to 8 Days
$346.50
Details
Bat Goat Un-conjugated IHC (p) Immunohistochemistry-Paraffin: Clathrin Heavy Chain 1/CHC17 Antibody [NBP1-52529] - Analysis of anti-CLTC antibody with human kidney at concentration 3.75 ug/ml. Immunohistochemistry-Paraffin: Clathrin Heavy Chain 1/CHC17 Antibody [NBP1-52529] - Analysis of anti-CLTC antibody with human adrenal at concentration 3.75 ug/ml. 0.05 mg Log in to see 10 to 13 Days
$556.31
Details

CLTC Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-clathrin, Heavy Chain (Hc) Antibodies

  1. Cow (Bovine) Monoclonal CLTC Primary Antibody for ICC, FACS - ABIN152766 : Fernandez, McVicker, Tuma, Tuma: Ethanol selectively impairs clathrin-mediated internalization in polarized hepatic cells. in Biochemical pharmacology 2009 (PubMed)
    Show all 6 Pubmed References

  2. Cow (Bovine) Monoclonal CLTC Primary Antibody for WB - ABIN265878 : Grossman, Ebke, Beight, Jang, Crabb, Hagstrom: Protein partners of dynamin-1 in the retina. in Visual neuroscience 2013 (PubMed)

  3. Human Polyclonal CLTC Primary Antibody for IF (p) - ABIN891159 : Kuhn, Vanhecke, Michen, Blank, Gehr, Petri-Fink, Rothen-Rutishauser: Different endocytotic uptake mechanisms for nanoparticles in epithelial cells and macrophages. in Beilstein journal of nanotechnology 2014 (PubMed)

More Antibodies against clathrin, Heavy Chain (Hc) Interaction Partners

Human clathrin, Heavy Chain (Hc) (CLTC) interaction partners

  1. miR (show MLXIP Antibodies)-579-3p controls melanoma progression and resistance to target therapy by targeting the 3'UTR (show UTS2R Antibodies) of two oncoproteins: BRAF (show BRAF Antibodies) and MDM2 (show MDM2 Antibodies).

  2. Durable (>/=3 years) survival is achievable with dabrafenib plus trametinib in patients with BRAF (show BRAF Antibodies) V600-mutant metastatic melanoma

  3. A high extent more than 25% of BRAF (show BRAF Antibodies)(V600E) alleles may be associated with disease outcome in PTC (show F9 Antibodies) patients.

  4. Study found that high expression of LC3B (show MAP1LC3B Antibodies) protein was associated with the presence of BRAF (show BRAF Antibodies) V600E mutation and temporal lesion in glioneuronal tumors, as well as in gangliogliomas alone. As for Beclin-1 protein (show BECN1 Antibodies), it showed statistically significant correlation with BRAF (show BRAF Antibodies) V600E mutation in glioneuronal tumors.

  5. We suggest that BRAF (show BRAF Antibodies) mutant patients should not be considered as having a unique biology and provide an in depth characterization of heterogeneous motifs that may be exploited for drug targeting.

  6. The results establish a link between BRAF (show BRAF Antibodies)(V600E) and NOX4 (show NOX4 Antibodies), which is confirmed by a comparative analysis of NOX4 (show NOX4 Antibodies) expression in human (TCGA) and mouse thyroid cancers.

  7. PD-L1 (show CD274 Antibodies) expression in colorectal cancer is associated with microsatellite instability and BRAF (show BRAF Antibodies) mutations.

  8. Results indicate that MAPK (show MAPK1 Antibodies) pathway inhibition leads to changes in the immunological properties of mutant BRAF (show BRAF Antibodies) melanoma cells.

  9. Results show that promoter mutations render telomerase reverse transcriptase (TERT (show TERT Antibodies)) expression dependent on MAPK (show MAPK1 Antibodies) signal pathway activation due to oncogenic BRAF (show BRAF Antibodies) or NRAS (show NRAS Antibodies) mutations.

  10. Of these 6 patients, 3 had a BRAF (show BRAF Antibodies) mutation positive primary with a BRAF (show BRAF Antibodies) mutation negative metastatic lesion, while the other 3 had a BRAF (show BRAF Antibodies) mutation negative primary with BRAF (show BRAF Antibodies) mutation positive metastasis.There is an important discordance rate in the BRAF (show BRAF Antibodies) mutation status of melanoma primaries versus brain metastases.

Caenorhabditis elegans (C. elegans) clathrin, Heavy Chain (Hc) (CLTC) interaction partners

  1. The clathrin heavy chain CHC-1 negatively regulates pulling forces acting on centrosomes during interphase and on spindle poles during mitosis in one-cell C. elegans embryos.

  2. Inactivating epn-1 (show EPN1 Antibodies) or chc-1 disrupts engulfment by impairing actin polymerization. CHC-1 is enriched on extending pseudopods together with EPN-1 (show EPN1 Antibodies), in an EPN-1 (show EPN1 Antibodies)-dependent manner.

  3. These results indicate that a high level of CHC activity is required for receptor-mediated endocytosis in nonneuronal cells but is largely dispensable for maintenance of synaptic vesicle pools.

  4. Loss of SNX-1 (show SNX1 Antibodies), RME-8, or the clathrin chaperone Hsc70 (show HSPA8 Antibodies)/HSP-1 leads to over-accumulation of endosomal clathrin, reduced clathrin dynamics, and missorting of MIG-14 (show RAE1 Antibodies) to the lysosome.

Pig (Porcine) clathrin, Heavy Chain (Hc) (CLTC) interaction partners

  1. Taken together, these results demonstrate that Japanese encephalitis virus enters porcine kidney epithelial PK15 cells through cholesterol- and clathrin-mediated endocytosis.

  2. Clathrin plays a crucial role in meiotic spindle function in maturing oocytes, possibly through spindle stabilization

Cow (Bovine) clathrin, Heavy Chain (Hc) (CLTC) interaction partners

  1. three different clathrin-box motif peptides can each simultaneously bind not only to the previously characterized clathrin-box site but also to the W-box site and the beta-arrestin splice loop site on a single TD.

  2. Structure of clathrin coat with bound Hsc70 (show HSPA8 Antibodies) and auxilin (show DNAJC6 Antibodies).

  3. clathrin-FKBP36-Hsp72 complexes resulting from both identified interactions are bound to the matrices of clathrin-coated vesicles in spermatocytes, which indicates a possible role of FKBP36 and Hsp72 in the disassembly of clathrin coats

Mouse (Murine) clathrin, Heavy Chain (Hc) (CLTC) interaction partners

  1. our results demonstrate that CKAP5 (show CKAP5 Antibodies) is important in oocyte maturation and early embryo development, and CKAP5 (show CKAP5 Antibodies) might work together with CLTC in mouse oocyte maturation

  2. SP-A (show SFTPA1 Antibodies) transiently enhances the basal protein expression of CHC and alpha-adaptin (show AP2A2 Antibodies).

  3. MiR (show MLXIP Antibodies)-199a-5p suppresses tumorigenesis by targeting CLTC in hepatocellular carcinoma.

  4. PTEN-like domains of GAK and auxilin are not essential for Hsc70-dependent chaperoning and uncoating of clathrin, but depending on the tissue, these domains appear to increase the efficiency of these co-chaperones.

  5. The clathrin-mediated endocytic machinery combines with Dab2 (show DAB2 Antibodies) to facilitate the endocytosis of RGD-integrin-beta3 clusters.

  6. Taken together, these results show that CLTC plays an important role in spindle assembly and chromosome congression through a microtubule correlation mechanism during mouse oocyte maturation.

  7. Auditory inner hair cells use dynamin-dependent endocytosis via clathrin-mediated endocytosis.

  8. Data indicate that dynamin (show DNM1 Antibodies), clathrin, adaptor protein complex-2 (AP2 (show TFAP2A Antibodies)), and amphiphysin (show AMPH Antibodies) contribute to the depolarization-evoked entry in endocytosis.

  9. This study reveals a novel functional role of clathrin-coated structure in GMR (show CSF2RA Antibodies) signaling and the oncogenesis of JAK2V617F.

  10. The authors report that Dab2, previously described as an inhibitor of Wnt/beta-catenin signalling, selectively recruits LRP6 to the clathrin-dependent endocytic route, thereby sequestering it from caveolin-mediated endocytosis.

Arabidopsis thaliana clathrin, Heavy Chain (Hc) (CLTC) interaction partners

  1. Data indicate that MTV1 (AT3G16270) and AGD5 (AT5G54310) Physically Interact with clathrin.

  2. study presents a genetic characterization of the role of clathrin in endocytosis and auxin-mediated plant development; data demonstrate a fundamental role for clathrin function in cell polarity, growth, patterning, and organogenesis

clathrin, Heavy Chain (Hc) (CLTC) Antigen Profile

Protein Summary

Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.

Gene names and symbols associated with CLTC

  • B-Raf proto-oncogene, serine/threonine kinase (BRAF) antibody
  • clathrin heavy chain (CHC1) antibody
  • Probable clathrin heavy chain 1 (chc-1) antibody
  • clathrin heavy chain (CLTC) antibody
  • clathrin heavy chain (Chc) antibody
  • clathrin heavy chain (TP03_0480) antibody
  • clathrin heavy chain (LOC5578293) antibody
  • putative clathrin heavy chain (LMJF_36_1630) antibody
  • clathrin heavy chain (CpipJ_CPIJ014882) antibody
  • clathrin heavy chain 1 (CNJ03270) antibody
  • clathrin heavy chain 1 (ATEG_05434) antibody
  • clathrin heavy chain 1 (CMU_025200) antibody
  • clathrin heavy chain (PMAA_094250) antibody
  • clathrin heavy chain Chc1 (SJAG_02282) antibody
  • clathrin heavy chain (Smp_154420.1) antibody
  • clathrin heavy chain 1 (PAAG_00730) antibody
  • clathrin heavy chain (MCYG_06136) antibody
  • clathrin heavy chain 1 (VDBG_05048) antibody
  • clathrin heavy chain 1 (MGYG_04658) antibody
  • clathrin heavy chain (cgd8_1270) antibody
  • clathrin heavy chain (Tc00.1047053506167.50) antibody
  • clathrin heavy chain (CHC) antibody
  • clathrin, heavy polypeptide (Hc) (Cltc) antibody
  • clathrin heavy chain (Cltc) antibody
  • Clathrin, heavy chain (AT3G11130) antibody
  • clathrin, heavy chain (Hc) L homeolog (cltc.L) antibody
  • 3110065L21Rik antibody
  • B-RAF1 antibody
  • BRAF1 antibody
  • Chc antibody
  • CHC17 antibody
  • CLH-17 antibody
  • cltc antibody
  • CLTCL2 antibody
  • F11B9.30 antibody
  • Hc antibody
  • NS7 antibody
  • R74732 antibody
  • RAFB1 antibody

Protein level used designations for CLTC

94 kDa B-raf protein , B-Raf proto-oncogene serine/threonine-protein kinase (p94) , murine sarcoma viral (v-raf) oncogene homolog B1 , proto-oncogene B-Raf , serine/threonine-protein kinase B-raf , v-raf murine sarcoma viral oncogene homolog B1 , clathrin heavy chain , Clathrin Heavy Chain family member (chc-1) , clathrin heavy chain 1 , clathrin heavy-chain , clathrin, heavy polypeptide (Hc) , clathrin heavy chain on chromosome 17 , clathrin, heavy polypeptide-like 2 , clathrin, heavy chain (Hc) , clathrin, heavy chain (Hc) L homeolog

GENE ID SPECIES
673 Homo sapiens
5725357 Chlamydomonas reinhardtii
176434 Caenorhabditis elegans
395272 Gallus gallus
100271929 Sus scrofa
100233163 Bombyx mori
1213 Homo sapiens
3499985 Theileria parva strain Muguga
5578293 Aedes aegypti
5655418 Leishmania major strain Friedlin
6047964 Culex quinquefasciatus
281080 Bos taurus
455168 Pan troglodytes
3254223 Cryptococcus neoformans var. neoformans JEC21
4320947 Aspergillus terreus NIH2624
6995013 Cryptosporidium muris RN66
7026543 Talaromyces marneffei ATCC 18224
7049029 Schizosaccharomyces japonicus yFS275
8340532 Schistosoma mansoni
9100448 Paracoccidioides sp. 'lutzii' Pb01
9227238 Arthroderma otae CBS 113480
9532124 Verticillium alfalfae VaMs.102
10027332 Arthroderma gypseum CBS 118893
100228172 Taeniopygia guttata
480578 Canis lupus familiaris
3374266 Cryptosporidium parvum Iowa II
3540437 Trypanosoma cruzi strain CL Brener
7449343 Thalassiosira pseudonana CCMP1335
67300 Mus musculus
54241 Rattus norvegicus
820284 Arabidopsis thaliana
444287 Xenopus laevis
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