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PACS1 encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Additionally we are shipping and many more products for this protein.
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study showed for the first time that the rs564343 in phosphofurin acidic cluster sorting protein 1(PACS1) was associated with risk of severe obesity in Chinese children
Clinical description of the PACS1-related syndrome has been reported in 19 unrelated patients.
PACS1 plays an important role in protein sorting for amyloidogenic-burden control via both SORLA (show SORL1 Antibodies)-dependent and SORLA (show SORL1 Antibodies)-independent mechanisms.
Our findings suggest that PACS1 is necessary for the formation of craniofacial structures and that perturbation of its functions results in a specific syndromic ID phenotype.
PACS-1 along with HIV-1 nef, has a role in downregulating cell surface MHC (show HLAE Antibodies)-I to the trans-Golgi network and usurping the ARF6 (show ARF6 Antibodies) endocytic pathway
subcellular localization and function of polycystin-2 (show PKD2 Antibodies) are directed by phosphofurin acidic cluster sorting protein (PACS)-1 and PACS-2 (show PACS2 Antibodies)
casein kinase 2 induces PACS-1 binding of nephrocystin (show NPHP1 Antibodies) and targeting to cilia
CK2 (show CSNK2A1 Antibodies)-activated phosphorylation cascade controlling PACS-1- and GGA3 (show GGA3 Antibodies)-mediated CI-MPR (show IGF2R Antibodies) sorting, is reported.
PACS-1 mediates phosphorylation-dependent ciliary trafficking of the CNGB1b (show CNGB1 Antibodies) in olfactory sensory neurons.
This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance.
, cytosolic sorting protein PACS-1