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Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. Additionally we are shipping PACS2 Proteins (4) and and many more products for this protein.
Showing 10 out of 31 products:
Human Polyclonal PACS2 Primary Antibody for IHC, IHC (p) - ABIN4343360
Aslan, You, Williamson, Endig, Youker, Thomas, Shu, Du, Milewski, Brush, Possemato, Sprott, Fu, Greis, Runckel, Vogel, Thomas: Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis. in Molecular cell 2009
Protein adaptation and the expanding roles of the PACS1 (show PACS1 Antibodies) and PACS2 proteins in tissue homeostasis and disease has been summarized. (Review)
Missense Mutation in PACS2 gene is associated with Neurodevelopmental Disorders.
cIAPs constitutively downregulate PACS-2 by polyubiquitination and proteasomal degradation, thereby restraining TRAIL-induced killing of liver cancer cells
Tumor necrosis factor (show TNF Antibodies)-related apoptosis-inducing ligand (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2.
subcellular localization and function of polycystin-2 (show PKD2 Antibodies) are directed by phosphofurin acidic cluster sorting protein (PACS)-1 (show PACS1 Antibodies) and PACS-2
PACS-2 as a novel sorting protein that links the endoplasmic reticulum (ER)-mitochondria axis to ER homeostasis
PACS-2 is required for Nef action and sorting of itinerant membrane cargo in the TGN (show TG Antibodies)/endosomal system
the phosphorylation state of the calnexin (show CANX Antibodies) cytosolic domain and its interaction with PACS-2 sort the chaperone between domains of the ER and the plasma membrane
Results identify PACS-2 as an essential TRAIL effector, and show that Akt (show AKT1 Antibodies) cooperates with 14-3-3 (show YWHAQ Antibodies) to regulate the homeostatic and apoptotic properties of PACS-2 that mediate TRAIL action.
PACS-2 coordinates p53 (show TP53 Antibodies)/p21 (show D4S234E Antibodies)- dependent cell cycle arrest with NF-kappaB (show NFKB1 Antibodies)/Bcl-xL (show BCL2L1 Antibodies)-dependent pro-survival signaling to support DNA repair in response to genotoxic damage.
CS-2 (show MYOZ1 Antibodies) traffics to the nucleus where it regulates SIRT1 (show SIRT1 Antibodies)-mediated p53 (show TP53 Antibodies) deacetylation. PACS-2 binds SIRT1 (show SIRT1 Antibodies) in vitro and directly inhibits SIRT1 (show SIRT1 Antibodies)-catalyzed p53 (show TP53 Antibodies) deacetylation.
Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.