anti-phosphofurin Acidic Cluster Sorting Protein 2 (PACS2) Antibodies

Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. Additionally we are shipping PACS2 Proteins (4) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PACS2 23241 Q86VP3
PACS2 217893  
PACS2    
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Top anti-PACS2 Antibodies at antibodies-online.com

Showing 10 out of 29 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-PACS2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: A549 cell lysate 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of human brain tissue, using PACS2-Specific antibody. ABIN6273285 at 1/100 staining Human pancreas cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) 0.05 mg 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated IHC (p), WB PACS2 Antibody (C-term) (ABIN657066) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ELISA, IF, IHC (p), WB   0.1 mg 2 to 3 Days
$360.00
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemical staining of human liver with PACS2 polyclonal antibody  shows strong cytoplasmic positivity in hepatocytes at 1:50-1:200 dilution. 100 μL 11 to 12 Days
$577.33
Details
Human Rabbit Biotin IHC, ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details
Human Rabbit APC IHC, ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details
Human Rabbit Alkaline Phosphatase (AP) IHC, ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details
Human Rabbit FITC IHC, ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details

Top referenced anti-PACS2 Antibodies

  1. Human Polyclonal PACS2 Primary Antibody for IHC, IHC (p) - ABIN4343360 : Aslan, You, Williamson, Endig, Youker, Thomas, Shu, Du, Milewski, Brush, Possemato, Sprott, Fu, Greis, Runckel, Vogel, Thomas: Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis. in Molecular cell 2009 (PubMed)

More Antibodies against PACS2 Interaction Partners

Human phosphofurin Acidic Cluster Sorting Protein 2 (PACS2) interaction partners

  1. Insulin acutely regulates SIRT1 activity by triggering recruitment of PACS-2 and DBC1 to the SIRT1 N terminal region creating a regulatory hub.

  2. These findings support the causality of this recurrent de novo PACS2 heterozygous missense in Developmental and epileptic encephalopathies with facial dysmorphim and cerebellar dysgenesis.

  3. Protein adaptation and the expanding roles of the PACS1 and PACS2 proteins in tissue homeostasis and disease has been summarized. (Review)

  4. Missense Mutation in PACS2 gene is associated with Neurodevelopmental Disorders.

  5. cIAPs constitutively downregulate PACS-2 by polyubiquitination and proteasomal degradation, thereby restraining TRAIL-induced killing of liver cancer cells

  6. The sites on Nef and the PACS proteins required for their interaction, are identified.

  7. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2.

  8. subcellular localization and function of polycystin-2 are directed by phosphofurin acidic cluster sorting protein (PACS)-1 and PACS-2

  9. PACS-2 as a novel sorting protein that links the endoplasmic reticulum (ER)-mitochondria axis to ER homeostasis

  10. PACS-2 is required for Nef action and sorting of itinerant membrane cargo in the TGN/endosomal system

  11. the phosphorylation state of the calnexin cytosolic domain and its interaction with PACS-2 sort the chaperone between domains of the ER and the plasma membrane

  12. Results identify PACS-2 as an essential TRAIL effector, and show that Akt cooperates with 14-3-3 to regulate the homeostatic and apoptotic properties of PACS-2 that mediate TRAIL action.

Mouse (Murine) phosphofurin Acidic Cluster Sorting Protein 2 (PACS2) interaction partners

  1. Insulin acutely regulates SIRT1 activity by triggering recruitment of PACS-2 and DBC1 to the SIRT1 N terminal region creating a regulatory hub.

  2. PACS-2 coordinates p53/p21- dependent cell cycle arrest with NF-kappaB/Bcl-xL-dependent pro-survival signaling to support DNA repair in response to genotoxic damage.

  3. CS-2 traffics to the nucleus where it regulates SIRT1-mediated p53 deacetylation. PACS-2 binds SIRT1 in vitro and directly inhibits SIRT1-catalyzed p53 deacetylation.

  4. PACS-2 is required for Nef action and sorting of itinerant membrane cargo in the TGN/endosomal system

  5. Results identify PACS-2 as an essential TRAIL effector, and show that Akt cooperates with 14-3-3 to regulate the homeostatic and apoptotic properties of PACS-2 that mediate TRAIL action.

PACS2 Antigen Profile

Protein Summary

Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.

Gene names and symbols associated with PACS2

  • phosphofurin acidic cluster sorting protein 2 (PACS2) antibody
  • phosphofurin acidic cluster sorting protein 2 (Pacs2) antibody
  • 6720425G15Rik antibody
  • AW208651 antibody
  • AW489976 antibody
  • E230011J22 antibody
  • mKIAA0602 antibody
  • PACS-2 antibody
  • Pacs1l antibody

Protein level used designations for PACS2

PACS1-like protein , PACS-2

GENE ID SPECIES
23241 Homo sapiens
217893 Mus musculus
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