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The protein encoded by SPINK1 is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. Additionally we are shipping serine Peptidase Inhibitor, Kazal Type 1 Antibodies (79) and serine Peptidase Inhibitor, Kazal Type 1 Kits (23) and many more products for this protein.
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3 siblings with near identical clinical manifestations of early onset acute recurrent pancreatitis (ARP (show CRISP1 Proteins)), all possessing the same heterozygous for serine protease inhibitor, Kazal type 1 (SPINK1) mutation c.55+1G>A.
We demonstrate for the first time a significant decrease of SPINK1 levels after surgical decompression of pancreatic duct and a reduction of trypsin activity analysis after endoscopic decompression
SPINK1 over expression is associated with prostate cancer specific mortality in at risk men with biochemical and clinical recurrence after prostatectomy
Data show that alteration in beta-catenin (show CTNNB1 Proteins) expression, a core component of the CDH17/beta-catenin (show CTNNB1 Proteins) axis, in tumors affects serine peptidase inhibitor Kazal type 1 (SPINK1) serum levels in hepatocellular carcinoma (HCC (show FAM126A Proteins)) patients.
Findings indicate that the serine protease inhibitor, Kazal type 1 (SPINK1) p.N34S allele may cause reduced SPINK1 expression.
Having correlated our findings with current knowledge of SPINK1's role in exocrine pancreas pathophysiology, we propose that complete and partial functional losses of the SPINK1 gene are associated with quite distinct phenotypes, the former causing a new pediatric disease entity of severe infantile isolated exocrine pancreatic insufficiency (EPI (show TFPI Proteins)) .
results suggest that rs142703147:C>A, which disrupts a PTF1L-binding site within an evolutionarily conserved HNF1A (show HNF1A Proteins)-PTF1L cis (show CISH Proteins)-regulatory module located upstream of the SPINK1 promoter, contributes to the chronic pancreatitis risk haplotype.
Studied mutations in cationic trypsinogen (PRSS1 (show PRSS1 Proteins)) and serine protease inhibitor Kazal type 1 (SPINK1) and their association with alcoholic chronic pancreatitis (ACP (show NDUFAB1 Proteins)) and idiopathic chronic pancreatitis.
Studies indicate that serine peptidase inhibitor Kazal type 1 (SPINK1) gene, particularly the N34S mutation, has a genetic association with the development of pancreatitis [Meta-analysis].
association between SPINK1 p.N34S gene variation and chronic pancreatitis [review, meta-analysis]
Partially folded bovine pancreatic trypsin inhibitor analogues attain fully native structures when co-crystallized with S195A rat trypsin.
It is a trypsin-specific inhibitor in the pancreas.
IFN regulatory factor 2 (Irf2 (show IRF2 Proteins)) has a regulatory role in trypsinogen5 gene transcription, which is resistant to a major endogenous trypsin inhibitor, Spink3
SPINK3 modulates sperm physiology through a downstream reduction of endogenous NO concentration and independently of SPINK3 trypsin inhibitory activity.
uterine-gland-derived SPINK3, as a new paracrine modulator, might play an important role in embryo implantation through its influence on stromal decidualization in mice.
Spink3 may act as a growth factor, leading to cell proliferation and regeneration of tissue structure.
Results suggest that regulation of Prss1 (show PRSS1 Proteins) and Spink3 expression is involved in the susceptibility to experimentally induced pancreatitis.
Spink3 trypsin inhibitor is required for normal pancreatic development. Data indicate an important relationship between endogenous pancreatic trypsin and Spink3 and the development of pancreatitis.
SPINK3 mRNA is upregulated in chronic pancreatitis.
Spink3 may play important roles in proliferation and/or differentiation of various cell types during development.
The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis.
pancreatic secretory trypsin inhibitor
, serine protease inhibitor Kazal-type 1
, serine protease inhibitor, Kazal type 1
, tumor-associated trypsin inhibitor
, calcium transport inhibitor
, pancreatic secretory trypsin inhibitor II
, pancreatic secretory trypsin inhibitor type II (PSTI-II)
, serine peptidase inhibitor, Kazal type 3
, serine protease inhibitor Kazal-type 3
, serine protease inhibitor, Kazal type 3
, serine peptidase inhibitor, Kazal type 1
, prostatic secretory glycoprotein