SPINK1 Protein (His tag)
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- Target See all SPINK1 Proteins
- SPINK1 (serine Peptidase Inhibitor, Kazal Type 1 (SPINK1))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Human Cells
- Purification tag / Conjugate
- This SPINK1 protein is labelled with His tag.
- Purpose
- Recombinant Human SPINK1 Protein (His Tag)
- Sequence
- Asp24-Cys79
- Characteristics
- Recombinant Human Serine Protease Inhibitor Kazal-Type 1 is produced by our Mammalian expression system and the target gene encoding Asp24-Cys79 is expressed with a 6His tag at the C-terminus.
- Purity
- > 85 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product SPINK1 Protein
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serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) (AA 24-79) protein (His tag)
SPINK1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) (AA 1-79) protein (GST tag)SPINK1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) (AA 24-79) protein (GST tag)SPINK1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) (AA 24-79) protein (His tag)Crystallography grade SPINK1 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) (AA 24-80) protein (His tag)Crystallography grade SPINK1 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) proteinSPINK1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM MES, 150 mM NaCl, 2 mM CaCl2, 1 mM DTT, 0.05 % Brij35, 10 % Glycerol, pH 6.0.
- Storage
- -20 °C
- Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Target
- SPINK1 (serine Peptidase Inhibitor, Kazal Type 1 (SPINK1))
- Alternative Name
- SPINK1 (SPINK1 Products)
- Synonyms
- PCTT Protein, PSTI Protein, Spink3 Protein, TATI Protein, TCP Protein, Psti Protein, SPINK1 Protein, p12 Protein, serine peptidase inhibitor, Kazal type 1 Protein, SPINK1 Protein, Spink1 Protein
- Background
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Background: Serine Protease Inhibitor Kazal-Type 1 (SPINK1) is a trypsin inhibitor that prevent the trypsin-catalyzed premature activation of zymogens within the pancreas. Defects in SPINK1 are a cause of pancreatitis (PCTT). A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks. Defects in SPINK1 are the cause of susceptibility to tropical calcific pancreatitis (TCP). Recombinant SPINK1 protein (rSPINK1) stimulated cell proliferation in benign RWPE as well as cancerous prostate cells. The research result indicated that the potential of SPINK1 as an extracellular therapeutic target in prostate cancer. In contrast, knockdown of SPINK1 in 22RV1 cells inhibited cell proliferation, cell invasion, and tumor growth in xenograft assays.
Synonym: Pancreatic Secretory Trypsin Inhibitor, Serine Protease Inhibitor Kazal-Type 1, Tumor-Associated Trypsin Inhibitor, TATI, SPINK1, PSTI
- Molecular Weight
- 7.3 kDa
- UniProt
- P00995
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