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The protein encoded by SPINT1 is a member of the Kunitz family of serine protease inhibitors. Additionally we are shipping serine Peptidase Inhibitor, Kunitz Type 1 Antibodies (82) and serine Peptidase Inhibitor, Kunitz Type 1 Kits (8) and many more products for this protein.
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Data suggest that HAI1, a protease on the surface of colon carcinoma cells, is an MMP7 (show MMP7 Proteins) substrate; proteolysis by MMP7 (show MMP7 Proteins) releases extracellular region as soluble HAI1 (sHAI1); sHAI1 induces cancer cell aggregation; cholesterol sulfate is required for MMP-7 (show MMP7 Proteins)--catalyzed generation of sHAI1. (HAI1 = hepatocyte growth factor activator inhibitor type 1; MMP7 (show MMP7 Proteins) = matrix metalloproteinase-7 (show MMP7 Proteins))
Concomitant presence of TMPRSS13 (show TMPRSS13 Proteins) with HAI-1 mediates phosphorylation of residues in the intracellular domain of the protease, and it coincides with efficient transport of the protease to the cell surface and its subsequent shedding.
our data illustrated a novel pathway comprising miR (show MLXIP Proteins)-221and miR (show MLXIP Proteins)-222 and hepatocyte growth factor activator inhibitor type 1 in gastric cancer, which is a potential target for future clinical use
DNA methylation (show HELLS Proteins) levels in the COASY (show COASY Proteins) and SPINT1 promoter regions were considered to potentially be a convenient and useful biomarker for diagnosis of Alzheimer's Disease and Amnestic Mild Cognitive Impairment.
The structural insights gained here improve our understanding of the regulation of HAI-1 inhibitory activities and point to new approaches for better controlling these activities.
The present study demonstrated that ovarian cancer cell metastasis and invasion were more dependent on upregulation of matriptase (show ST14 Proteins) levels than downregulation of HAI1. Matriptase (show ST14 Proteins) may be a potential adjuvant therapeutic target for inhibiting ovarian cancer invasion and metastasis.
The findings suggest that the oncogenic activity of hepsin (show HPN Proteins) arises not only from elevated expression level but also from depletion of HAI-1, events which together trigger gain-of-function activity impacting HGF (show HGF Proteins)/MET signalling and epithelial cohesion
HAI-1 may have a critical role in maintaining normal keratinocyte morphology through regulation of PAR-2 (show F2RL1 Proteins)-dependent p38 mitogen-activated protein kinase (show MAPK14 Proteins) signaling.
the anti-migratory effects seen via gamma-catenin were driven by the expression of hepatocyte growth factor activator inhibitor Type I (HAI-1 or SPINT-1), an upstream inhibitor of the c-MET signaling pathway.
Data suggest HAI1 exhibits structural features consistent with classification in MANEC subclass of PAN/apple domain family with unifying features such as two additional disulfide bonds, two extended loop regions, and additional alpha-helical elements.
By completing our structural characterization of the previously unknown N-terminal region of HAI-1, we provide new insight into the interplay between tertiary structure and the inhibitory activity of a multidomain protease inhibitor
HAI-1 regulates the activity of activated matriptase (show ST14 Proteins), whereas HAI-2 (show SPINT2 Proteins) has an essential role in regulating prostasin (show PRSS8 Proteins)-dependent matriptase (show ST14 Proteins) zymogen activation.
HAI-1 and HAI-2 influence proliferation and cell fate of NPCs and their expression levels are linked to BMP sign
HAI-1/SPINT1 has a crucial role in suppressing intestinal tumorigenesis, which implies a novel link between epithelial cell surface (show EPCAM Proteins) serine protease (show F2 Proteins) inhibitors and protection from carcinogenic stimuli.
mutations in Prss8 (show PRSS8 Proteins) restored placentation and normal development of HAI-1-deficient embryos and prevented early embryonic lethality, mid-gestation lethality due to placental labyrinth failure, and neural tube defects in HAI-2 (show SPINT2 Proteins)-deficient embryos.
HAI-1 has a crucial suppressive role in oral squamous cell carcinoma cells' invasiveness.
HAI-1 and -2 are overexpressed in the liver in cholangiopathies with ductular reactions and are possibly involved in liver fibrosis and hepatic differentiation.
HAI-1/SPINT1 plays an important role in maintaining colonic epithelium integrity.
HAI-1 is required for branching morphogenesis in the chorioallantoic placenta.
The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms.
serine peptidase inhibitor, Kunitz type 1
, kunitz-type protease inhibitor 1
, kunitz-type protease inhibitor 1-like
, hepatocyte growth factor activator inhibitor type 1
, serine protease inhibitor, Kunitz type 1
, hepatocyte growth factor activator inhibitor 1
, hepatocyte growth factor activator inhibitor-1