ADWX-1

Catalog No. ABIN1540017

Product Details

Target: ADWX-1

Application: Blocking Reagent (BR)

Purpose: ADWX-1 inhibits Kv1.3 channel with an IC50 of 1.89 pM

Sequence: Val-Gly-Ile-Asn-Val-Lys-Cys-Lys-His-Ser-Arg-Gln-Cys-Leu-Lys-Pro-Cys-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys-Thr-Asn-Gly-Lys-Cys-His-Cys-Thr-Pro-Lys-OH (Disulfide Bridges: Cys7-Cys27, Cys13-Cys32, Cys17-Cys34)

Application Details

Restrictions: For Research Use only

Handling

Target Details

Target: ADWX-1

Background: ADWX-1 is an optimised synthetic analog of the scorpion peptide BmKTx. ADWX-1 is known to block Kv1.3 channel with a high affinity (IC50 = 1.89 pM) and selectivity (340 fold higher than Kv1.1). ADWX1 appears to be an interesting therapeutic candidate to treat auto-immune disorders such as multiple sclerosis, type-1 diabetes, rheumatoid arthritis and psoriasis. This peptide is a valuable tool for studying the structure-function of Kv1.3 channel and auto-immunity mechanisms.

Molecular Weight: 4071.9 Da