Protoxin I (ProTx-I)

Catalog No. ABIN1540116

Quick Overview for Protoxin I (ProTx-I) (ABIN1540116)

Target: Protoxin I

Application: Blocking Reagent (BR)

Product Details

Purpose: ProTx-1 is a VGSC blocker

Sequence: Glu-Cys2-Arg-Tyr-Trp-Leu-Gly-Gly-Cys9-Ser-Ala-Gly-Gln-Thr-Cys15-Cys16-Lys-His-Leu-Val-Cys21-Ser-Arg-Arg-His-Gly-Trp-Cys28-Val-Trp-Asp-Gly-Thr-Phe-SerDisulfi de bridges: Cys2-Cys16, Cys9-Cys21, Cys15-Cys28

Application Details

Restrictions: For Research Use only

Handling

Target Details

Target: Protoxin I

Background: Protoxin I (ProTx I, beta-theraphotoxin-Tp1a) is a toxin that was originally isolated from the venom of Thrixopelma pruriens (Peruvian green velvet tarantula). This toxin reversibly inhibits the tetrodotoxin (TTX)-resistant channel Nav1.8 (IC50 = 27 nM) and TTX sensitive Nav channels such Nav1.2, Nav1.5 and Nav1.7 with IC50 values between 50 and 100 nM. Furthermore, ProTx-I shifts the voltage dependence activity of T-type Cav3.1 channels (IC50= 50 nM) without affecting the voltage dependence of inactivation.

Molecular Weight: 3987.50 Da