IL-36Ra (human) Matched Pair Detection Set
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- Target See all FIL1d products
- FIL1d (Interleukin 1 delta (FIL1d))
- Detection Method
- Colorimetric
- Method Type
- Sandwich ELISA
- Detection Range
- 0.78-50 ng/mL
- Minimum Detection Limit
- 0.78 ng/mL
- Application
- ELISA
- Sample Type
- Cell Culture Supernatant
- Specificity
- Detects human IL-36Ra.
- Cross-Reactivity
- Human
- Sensitivity
- 0.5 ng/mL
- Components
- 1 vial standard protein (1μg) (lyophilized) [STD] 1 vial coating antibody (270μl) [COAT] 1 vial detection antibody (120μl) [DET] 1 vial streptavidin-HRP (10μg) (lyophilized) [STREP]
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Storage
- -20 °C
- Storage Comment
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Short Term Storage: -20°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. - Expiry Date
- 12 months
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- Target
- FIL1d (Interleukin 1 delta (FIL1d))
- Alternative Name
- IL-36Ra (FIL1d Products)
- Background
- IL-36Ra/IL-1F5 is a highly and specific antagonist of the IL-1 receptor-related protein 2-mediated response to IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9). These cytokines bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. Recently mutations that affect the levels and the activity of IL-36Ra have been found in patients with pustular psoriasis, leading to enhanced production of inflammatory cytokines (IL-8 in particular) by keratinocytes.
- UniProt
- Q9UHA7
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