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anti-Human Cathepsin S Antibodies:
anti-Mouse (Murine) Cathepsin S Antibodies:
anti-Rat (Rattus) Cathepsin S Antibodies:
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Human Polyclonal Cathepsin S Primary Antibody for ICC, IF - ABIN4288275
Ma, Visser, Roelofsen, de Vries, Diepstra, van Imhoff, van der Wal, Luinge, Alvarez-Llamas, Vos, Poppema, Vonk, van den Berg: Proteomics analysis of Hodgkin lymphoma: identification of new players involved in the cross-talk between HRS cells and infiltrating lymphocytes. in Blood 2008
Show all 2 Pubmed References
Human Polyclonal Cathepsin S Primary Antibody for IHC, IHC (fro) - ABIN4288274
Otsuki, Sawada, Yodoya, Shinohara, Kato, Ohashi, Zhang, Imanaka-Yoshida, Shimpo, Maruyama, Komada, Mitani: Potential contribution of phenotypically modulated smooth muscle cells and related inflammation in the development of experimental obstructive pulmonary vasculopathy in rats. in PLoS ONE 2015
The single nucleotide polymorphisms (SNPs) of rs774320676 and rs928508030 of CTSS gene were related with risk for acute atherosclerotic cerebral infarction. The T allele at rs774320676 locus and G allele at rs928508030 locus of CTSS were genetic susceptibility genes of acute atherosclerotic cerebral infarction
The levels of cathepsin S were associated with the degree of airflow limitation and emphysema phenotype in COPD [chronic obstructive pulmonary disease].
Src, a non-receptor tyrosine kinase, might provide an effective therapeutic strategy to overcome triple-negative breast cance invasion and metastasis, which are mediated via the synergistic action of the lysosomal enzyme cathepsin S (CTSS) and gelatinase MMP-9.
Cathepsin S (CTSS) and Sirtuin-1 (SIRT1) played crucial roles in the pathogenesis of chronic obstructive pulmonary disease. In the present study, one single nucleotide polymorphism (SNP) in rs12068264 was discovered (in 385 individuals) to be associated with the susceptibility of chronic obstructive pulmonary disease in a Chinese Han population.
stimulates periodontal ligament cell proliferation, migration, and wound closure
Cells with reduced PAR-2 expression showed significantly reduced release of IL-6, TNF-alpha, IL-1beta, and MMP-9 into culture medium in response to acute CTSS, while IL-6, TNF-alpha, and MMP-9 were reduced in culture medium, and IL-6 and MMP-9 in cell lysates, after chronic CTSS.
Plasma apoA-I proteolysis is augmented in aortic valve stenosis and cathepsin S exerts the most deleterious effects on apoA-I integrity in humans.
The present data indicating that Cat-S activity increases with CKD progression suggest that Cat-S might be a therapeutic target to prevent cardiovascular complications in CKD.
High expression of CTSS was independently associated with lymph node metastasis (OR, 2.015; 95% CI, 1.225-3.315; P=0.006). Therefore, CTSS may serve as a predictive risk marker for the progression and prognosis of papillary thyroid cancer .
Authors show a significant increase of circulating CS levels in healthy female subjects induced by long-term physical activity.
This study therefore considerably improves our understanding of the molecular mechanism responsible for cathepsin S inhibition and facilitates the identification of potential novel selective inhibitors of cathepsin S.
cathepsin S is increased in periodontal cells and tissues under inflammatory and infectious conditions, suggesting a critical role of this autophagy-associated molecule in the pathogenesis of periodontitis.
Elevated cathepsin S activity was associated with collagen I degradation and thus might be involved in the progression of abdominal aortic aneurysms.
Cathepsin S was identified as the major IL-36gamma-activating protease expressed in epithelial cells.
Our results indicate that autophagy is essential for decreasing CTSS activity to inhibit tumor metastasis by hispolon treatment in cervical cancer; this finding provides a new perspective on molecular regulation.
These results revealed that CTSS can regulate EGFR signalling by facilitating EGF-mediated EGFR degradation.
This study suggested serum Cat S may be a potential biomarker for the diagnosis and prognosis of gastric cancer
Overall, these results indicate that exploitation of the cathepsin S activity in MPS tissues can be utilized to substantially lower non-target accumulation, suggesting this is a promising approach for the development of diagnostic and radiotherapeutic nanomedicine platforms.
Cathepsins V and S may serve as auxiliary diagnostic and/or prognostic markers in thymic epithelial tumors.
polymorphism of rs7534124 and rs1136774 in cathepsin S promoter may decrease the susceptibility of asthma in a Chinese Han population
the roles of CTSB/S and SIRT1 in the regulation of hepatic inflammation using primary parenchymal and non-parenchymal hepatic cell types and cell lines.
CatS(-/-) mice exhibited impaired social interaction and social novelty recognition in the three-chamber test.
Cathepsin S activity controls injury-related vascular remodeling via TLR2/p38MAPK/PI3K/Akt/p-HDAC6 signaling pathway.
Loss of Rab3D from secretory vesicles, leading to disproportionate Rab27-to-Rab3D activity, may contribute to the enhanced release of cathepsin S in tears of patients with Sjogren's syndrome.
Ctss induction during muscular dystrophy is a pathologic event that partially underlies disease pathogenesis, and its inhibition might serve as a new therapeutic strategy in Duchenne muscular dystrophy.
Demonstrate the utility of intracellular caspase 1 and extracellular CTSS proteolytic activities as surrogate biomarkers of lysosomal rupture and acute inflammation.
Fluorogen substrate, Mca-GRWPPMGLPWE-Lys(Dnp)-DArg-NH2 can detect CTSS activities in mouse antigen presenting cells.
Data show that cathepsins S (CatS) regulates CCL2 chemokine expression by modulation of CD74 antigen processing.
Cathepsin S activates MrgprC11 and evokes receptor-dependent scratching in mice.
cathepsin S deficiency alters the balance between adipocyte and osteoblast differentiation, increases bone turnover, and changes bone microarchitecture. Therefore, bone and fat metabolisms should be monitored when using cathepsin S inhibitors clinically
results identify Cat-S as a biased agonist of PAR2 that causes PAR2- and TRPV4-dependent inflammation and pain.
Cathepsin S contributes to macrophage migration via degradation of elastic fibre integrity to facilitate neointima formation of vein grafts
cysteine cathepsins B and S can directly cleave Rip1
CatS also reduced myocardial Smad2 and Smad3 activation and extra domain A fibronectin expression
CatS is involved in the secondary injury after traumatic brain injury
Disruption of CatS therefore induces hyperlocomotor activity due to failure to downscale the synaptic strength.
These results show a peripheral pivotal role of CatS in the development of neuropathic pain through the antigen-specific activation of CD4(+) T-cells
High cathepsin S promotes cancer growth and neovascularization.
Provide direct evidence that Cat S plays an important role in abdominal aortic aneurysm formation in apoE-deficient mice.
The cathepsin S deserves further evaluation as therapeutic targets to develop disease modifying drugs to treat Alzheimer's disease.
These results, together with those previously reported for other genes of this family, suggest that cathepsin genes play a role in defining economically important traits in pigs.
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
, cathepsin S
, cathepsin S, gene 1
, Cathepsin S