Browse our CLEC7A Proteins (CLEC7A)

Pig (Porcine) C-Type Lectin Domain Family 7, Member A (CLEC7A) interaction partners

1. These results suggest that functionally neutral polymorphisms in dectin-1 are widespread in pig populations

2. recognition of beta-glucans appeared cell type-specific as both dectin-1 and CR3 are involved in the beta-glucan-mediated responses in pig macrophages.

Mouse (Murine) C-Type Lectin Domain Family 7, Member A (CLEC7A) interaction partners

1. LRRK2 inhibitors decreased Dectin-1-induced TNF-alpha production by mouse dendritic cells and ameliorated dextran sodium sulfate-induced colitis.

2. Bone marrow-derived dendritic cells (BMDCs) from mice lacking expression of the homologous phosphatases Sts-1 and Sts-2 (Sts(-/-) mice) negatively regulate the activation of select pathways downstream of the key fungal pathogen pattern recognition receptor Dectin-1. Sts proteins negatively regulate phagocyte activation via regulating selective elements of the Dectin-1-Syk tyrosine kinase signaling axis.

3. Dectin-1/Dectin-2-induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses.

4. Results indicate that dectin1 activation by betaglucan exerts atherogenic effects via converting macrophages into M1 phenotype in an NFkappaBautophagydependent pathway.

5. Dectin-1 and Dectin-2 cleavage by NE and/or A. fumigatus-derived proteases results in an aberrant antifungal immune response.

6. mDectin-1, mDectin-2, and SIGN-R1 are decorated by N-glycan structures that can be recognized by the carbohydrate recognition domain of Gal-3.

7. the ligand-induced cooperative oligomer formation of Dectin-1 is physiologically relevant in sensing exogenous beta-glucan and triggering intracellular signaling.

8. Dectin-1expression was significantly upregulated in Fusarum solanum induced keratomycosis.

9. Dectin-1 plays an important role in host defense against systemic Candida glabrata infections.

10. These results identify dectin-1-activated dendritic cells as a powerful inducer of Th9 cells and antitumour immunity and may have important clinical implications.

11. These findings demonstrate that Dectin-1, Irak1, and Rip2 are involved in response to Aspergillus fumigatus infection. Dectin-1 modulates the expression of Irak1 and Rip2.

12. Feeding Guar gum fiber increases SOCS-1, TLR2 and dectin-1 expression in dextran sodium sulfate administered and normal mice.

13. Dectin-1 agonists selectively induce IgG1 class switching by direct stimulation of Dectin-1 on LPS-activated B cells resulting in selective production of IgG1.

14. These results suggest that the intracellular domain, not ligand-binding domain, of Dectin-1 determines the species-specific ligand profile.

15. this study shows the critical role of Dectin-1 for inflammasome activation, restriction of parasite replication in macrophages, and mouse resistance to Leishmania amazonensis infection in vivo

16. results demonstrate that Dectin-1-triggered Card9 signaling but not inflammasome activation can potently cross-prime Ag-specific cytotoxic T-cells, suggesting that this pathway would be a candidate for immunotherapy and vaccine development

17. Dectin 1 is highly expressed on macrophages in pancreatic ductal adenocarcinoma (PDA). Clec7a deletion is protective against PDA, however Clec7a does not have direct protumorigenic effects on transformed pancreatic ductal epithelial cells.

18. Dectin-1 does not play a major role in in phagocytosis and innate defense by phagocytes against Cryptococcus neoformans spores.

19. these results suggest that Dectin-1 expressed on CD11b(+) dendritic cells (DCs) senses some molecule(s) in house dust mite (HDM) extract and plays a critical role in the induction of HDM-induced allergic airway inflammation by inducing the expression of chemokine/chemokine receptors in DCs.

20. The sum of the data suggests that in contrast to IgG-based immune complexes boosting immune reactivity of antigen-presenting cells, secretory IgA produced during an ongoing immune response can, in addition to its known function of immune exclusion, modulate mucosal dendritic cell conditioning via specific interaction with Dectin-1 and SIGNR3.

Human C-Type Lectin Domain Family 7, Member A (CLEC7A) interaction partners

1. These results show the involvement of the Dectin-1 receptor in fungal recognition and its consequent participation in the induction of the killing mechanisms against P. brasiliensis

2. nonsense mutation in the CLEC7A gene, p.Tyr238X, rs16910526 and a novel homozygous frameshift variant in exon 27 of the DOCK8 gene, c.3193delA were identified in brothers with an immunodeficiency syndrome characterized by severe eczema, milk and egg allergies, infections, diarrhea, failure to thrive and, in two of the three, lymphoma lymphoma

3. Dectin-1/Dectin-2-induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses.

4. A significant association between polymorphisms in the gene that encode dectin-1 and invasive aspergillosis (systematic review).

5. The invertebrate tropomyosin presented in the context of impaired dectin-1 function, as observed in allergic individuals, leads to unrestrained IL-33 secretion and skewing of immune responses toward type 2 immunity.

6. Dectin-1 receptor blockage decreased the IL-12, IL-17, IL-10 and TNF-alpha levels indicating the participation of such receptor in the induction of these cytokines.

7. Dectin-1 is expressed on mDCs and is down-regulated after contact with A. fumigatus, indicating that mDCs recognize A. fumigatus via this receptor. Blocking of Dectin-1, followed by stimulation with depleted zymosan diminished the up-regulation of the T-cell co-stimulatory molecules CD40, CD80, HLA-DR and CCR7 on mDCs and led to decreased release of the cytokines TNF-alpha, IL-8, IL-1beta and IL-10.

8. this study shows that Dectin-1 is essential for IL-1beta production through JNK activation and apoptosis in Aspergillus fumigatus keratitis

9. high tumoral dectin-1 expression was an independent predictor of adverse clinical outcome in ccRCC patients. This molecule and established nomograms might help clinicians in future decision making and therapeutic developments

10. Dectin-1 may have therapeutic implications as a biomarker for metabolic dysregulation in humans.

11. theses data suggest miR-146a may play the potent negative feedback regulator in inflammatory response following Dectin-1 stimulation

12. These results suggest that the intracellular domain, not ligand-binding domain, of Dectin-1 determines the species-specific ligand profile.

13. Unique cytokine secretion and varying expression levels of n Dectin-1 isoforms on monocyte-derived cells may indicate distinct isoform usage as a cell type-specific mechanism of regulating anti-fungal immunity.

14. Dectin 1 is highly expressed on macrophages in pancreatic ductal adenocarcinoma.

15. Dectin-1-mediated activation of the Syk, MAPKs, PI3K and NF-kappaB signaling pathways contributes to F. proliferatum-stimulated CXCL-8 release from BEAS-2B cells and provides an important basis for developing novel therapeutic strategies in clinical allergy.

16. this study shows that curdlan inhibits tumor growth via activating dendritic cells through dectin-1 signaling

17. Dectin-1 is essential for efficient immune response against Mycobacteria.

18. dectin-1 has a role in glycyrrhetinic acid inhibition of contact hypersensitivity induced by trichophytin

19. study represents the first analysis demonstrating that harbouring polymorphisms of Dectin-1 (rs7309123) or TLR2 (rs5743708) represents an independent risk factor of developing IFD in patients with AML undergoing induction chemotherapy.

20. TREM-1 and Dectin-1 function concurrently in the corneal innate immune response by regulating inflammatory cytokine expression in fungal keratitis.

Cow (Bovine) C-Type Lectin Domain Family 7, Member A (CLEC7A) interaction partners

1. The relationship between CLEC7A genotype and susceptibility to paratuberculosis among Indian cattle is reported.

2. CLEC7a genetic variant c.589A>G was significantly associated (p = 0.008) with Mycobacterium avium ssp. paratuberculosis infection in Holsteins cattle.