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anti-Rat (Rattus) MMP2 Antibodies:
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Chicken Polyclonal MMP2 Primary Antibody for ICC, IF - ABIN152329
Krekoski, Neubauer, Graham, Muir: Metalloproteinase-dependent predegeneration in vitro enhances axonal regeneration within acellular peripheral nerve grafts. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2002
Show all 39 Pubmed References
Human Polyclonal MMP2 Primary Antibody for ELISA, ICC - ABIN4886669
Zhang, Chen, Qi, Wang, Xiao, Zhu: Inhibition of calcium-calmodulin-dependent kinase II suppresses cardiac fibroblast proliferation and extracellular matrix secretion. in Journal of cardiovascular pharmacology 2010
Show all 25 Pubmed References
Human Polyclonal MMP2 Primary Antibody for IHC (fro), IHC (p) - ABIN3044339
Li, Xu, Chu, Gao, Wang, Nie, Yang, Lv: Molecular mechanism of inhibitory effects of CD59 gene on atherosclerosis in ApoE (-/-) mice. in Immunology letters 2013
Show all 25 Pubmed References
Human Polyclonal MMP2 Primary Antibody for IF (p), IHC (p) - ABIN668286
Wu, Fan, Zhang, Ning, Zeng, Zhou, Li, Chen, Zhang, Wang, Hsieh, He: PI3K/Akt to GSK3?/?-catenin signaling cascade coordinates cell colonization for bladder cancer bone metastasis through regulating ZEB1 transcription. in Cellular signalling 2012
Show all 14 Pubmed References
Human Monoclonal MMP2 Primary Antibody for ICC, IHC (fro) - ABIN152258
Locke, Royce, Wainewright, Samuel, Tang: Comparison of airway remodeling in acute, subacute, and chronic models of allergic airways disease. in American journal of respiratory cell and molecular biology 2007
Show all 13 Pubmed References
Human Polyclonal MMP2 Primary Antibody for IF (p), IHC (p) - ABIN707426
Cavdar, Ozbal, Celik, Ergur, Guneli, Ural, Camsari, Guner: The effects of alpha-lipoic acid on MMP-2 and MMP-9 activities in a rat renal ischemia and re-perfusion model. in Biotechnic & histochemistry : official publication of the Biological Stain Commission 2014
Show all 4 Pubmed References
Guinea Pig Monoclonal MMP2 Primary Antibody for ELISA, ICC - ABIN152257
Rork, Hadzimichalis, Kappil, Merrill: Acetaminophen attenuates peroxynitrite-activated matrix metalloproteinase-2-mediated troponin I cleavage in the isolated guinea pig myocardium. in Journal of molecular and cellular cardiology 2006
Show all 3 Pubmed References
Human Monoclonal MMP2 Primary Antibody for ELISA, WB - ABIN1098146
Langers, Verspaget, Hawinkels, Kubben, van Duijn, van der Reijden, Hardwick, Hommes, Sier: MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients. in British journal of cancer 2012
Show all 2 Pubmed References
Human Monoclonal MMP2 Primary Antibody for ELISA, ICC - ABIN451535
Siddesha, Valente, Yoshida, Sakamuri, Delafontaine, Iba, Noda, Chandrasekar: Docosahexaenoic acid reverses angiotensin II-induced RECK suppression and cardiac fibroblast migration. in Cellular signalling 2014
Show all 2 Pubmed References
Human Monoclonal MMP2 Primary Antibody for CyTOF, FACS - ABIN4900818
Zhao, McCloud, Fleming, Klempner: Borrelia burgdorferi-induced monocyte chemoattractant protein-1 production in vivo and in vitro. in Biochemical and biophysical research communications 2007
Show all 2 Pubmed References
study demonstrated that matrix metalloproteinase 1 (show MMP1 Antibodies) and 2 might be fundamental for events related to equine tissue remodeling, which occurs during follicular development
inhibition of ECM (show MMRN1 Antibodies) degradation by inhibition of matrix metalloproteinase 2 (Mmp2) to preserve the extracellular environment characteristics of young adults led to increased dendrite regeneration
Data indicate that matrix metalloproteinases mmp1 (show MMP1 Antibodies) and mmp2 mutants have distinct heart phenotypes.
We also show that follicular OA-Oamb signaling induces Mmp2 enzymatic activation but not Mmp2 protein expression, likely via intracellular Ca2 (show CA2 Antibodies)+ as the second messenger.
Finally, matrix metalloproteinase 2 (Mmp2), a type of protease thought to facilitate mammalian ovulation, is expressed in mature follicle and corpus luteum cells.
As a Wnt (show WNT4 Antibodies) signaling antagonist, MMP2 cleaves the glypican (show GPC1 Antibodies), reducing the ability of Dlp (show DMD Antibodies) to interact with the Wnt (show WNT4 Antibodies) ligand and promote its distribution.
Matrix metalloproteinase 2 is required for fat-body remodeling in Drosophila
Drosophila MMP2 regulates the matrix molecule faulty attraction (Frac) to promote motor axon targeting in Drosophila.
Dendrite reshaping of adult Drosophila sensory neurons requires matrix metalloproteinase MMP2-mediated modification of the basement membranes
Mmp2 expression in the developing air sac (show ADCY10 Antibodies) is controlled by the Drosophila FGF homolog Branchless and then participates in a negative feedback and lateral inhibition mechanism that defines the precise pattern of FGF signaling.
findings demonstrate a critical role for Mmp2 in tubulogenesis post-induction, and implicate Mmp2 in regulating dynamic and essential changes to the extracellular matrix
Mmp2 facilitates endothelial-to-hematopoietic transition via ECM (show MMRN1 Antibodies) remodeling.
Dexamethasone and hydrocortisone alter expression and activity of MMP-2 and MMP-9 (show MMP9 Antibodies) in the embryonic zebrafish.
In obese mice, periodontitis caused the downregulation of MMP2, and upregulation of TIMP1 (show TIMP1 Antibodies) and TGF-beta1 (show TGFB1 Antibodies) at transcriptional and translational levels.
In the initial periods of AP progression, an increased expression of MMP9 (show MMP9 Antibodies) in the TLR2 KO and MyD88 (show MYD88 Antibodies) KO mice was observed. In the final periods of AP progression, a reduction of MMP2 expression and an increase of MMP9 (show MMP9 Antibodies) expression in the TLR2 KO mice were observed. MMP2 and MMP9 (show MMP9 Antibodies) production was modulated for TLR2 and MyD88 (show MYD88 Antibodies) during apical periodontitis progression
MMP-2 promoted and MMP-13 (show MMP13 Antibodies) disrupted vasculogenic mimicry formation in large cell lung cancer by cleaving laminin-5 to influence EGFR (show EGFR Antibodies) signal activation.
Diet and exercise affect atheromatous MMP2/9 activity by modulating the systemic inflammatory milieu, with sVCAM-1, resistin, and adiponectin closely interacting with each other and with visceral fat.
calpains inhibition plays crucial roles in vascular restenosis by preventing neointimal hyperplasia at the early stage via suppression of the MMP2/TGF-beta1 (show TGFB1 Antibodies) pathway.
Aneurysmal-prone factors induced HIF-1alpha (show HIF1A Antibodies) can cause overexpression of MMP-2 and MMP-9 (show MMP9 Antibodies) and promote aneurysmal progression.
These studies illustrated an important role of MMP2 in cognitive and motor behaviors and confirm its importance in NPC (show NPC1 Antibodies) activities crucial to brain development, growth and response to and recovery from injury.
Secretagogin (show SCGN Antibodies)-dependent MMP2 release from neurons regulates neuroblast migration.
matrix metalloproteinase 2 (Mmp2) transcript is a target of miR (show MLXIP Antibodies)-195a-3p, and that silencing Mmp2 phenocopied the reduced proliferation and migration of MSCs. The therapeutic potential of miR (show MLXIP Antibodies)-195a-3p as an angiogenesis inhibitor was also demonstrated in a laser-induced choroidal neovascularization mouse model.
developed a novel selective radiolabeled MMP2/9 inhibitor, suitable for single photon emission computed tomography (SPECT) imaging that effectively targets atherosclerotic lesions in mice
that miR (show MLXIP Antibodies)-338-5p has a function in promoting glioma cell invasion by targeting TSHZ3 (show ZNF537 Antibodies) suppression on MMP2
In dilation cardiomyopathy, expression of MMP-2, MMP-9 (show MMP9 Antibodies), and TIMP-1 (show TIMP1 Antibodies) and their ratios in autopsy material and in cultures was elevated by 1.5-9 times.
OSM (show OSM Antibodies) [oncostatin M (show OSM Antibodies)]might be involved in the invasiveness of extravillous trophoblasts under hypoxia conditions via increasing MMP-2 and MMP-9 (show MMP9 Antibodies) enzymatic activities through STAT3 (show STAT3 Antibodies) signaling. Increased MMP-9 (show MMP9 Antibodies) activity by OSM (show OSM Antibodies) seems to be more important in primary trophoblasts.
TIMP2 (show TIMP2 Antibodies) promotes tumor progression and miR2055p directly regulates TIMP2 (show TIMP2 Antibodies), thereby suppressing proMMP2 activation and inhibiting oral squamous cell carcinoma cell invasiveness.
Elevated MMP-2 levels were observed in blood of pancreatic cancer patients which correlated with its tissue expression. However, these levels did not associate with survival or any clinicopathological parameters of patients.
2G allele of MMP-1 (show MMP1 Antibodies), C allele of MMP-2 and 5A/6A genotype of MMP-3 (show MMP3 Antibodies) are associated with susceptibility and disease progression of type 2 diabetic nephropathy
Increased urinary concentration of matrix metallopeptidase 2 (MMP-2) at 12 and 16 weeks of gestation predicted an increased risk of developing preeclampsia in the study population.
There was no difference found in MMP-2, MMP-9 (show MMP9 Antibodies) or TLR-4 (show TLR4 Antibodies) levels between non-thrombocytopenic and thrombocytopenic septic donors. PLA formation was increased in thrombocytopenic patients.
MMP2 rs243865 was the only single nucleotide polymorphism significantly associated with Floppy Mitral Valve/Mitral Valve Prolapse (FMV/MVP (show MVP Antibodies)) as compared to the control.The frequency of certain MMP2 polymorphisms is higher in patients with the FMV/MVP (show MVP Antibodies) syndrome and patients with FMV/MVP (show MVP Antibodies) without the syndrome.
Specific silencing that targeted AMPK (show PRKAA1 Antibodies) resulted in the enhancement of mobility and contractility and in the production of MMP-1 (show MMP1 Antibodies) and MMP-2.
this study shows that differential FFAR1 (show FFAR1 Antibodies) signaling is associated with gene expression or gelatinase granule release in bovine neutrophils
NADPH oxidase (show NOX1 Antibodies) plays an important role in proMMP-2 expression and activation and MMP-2 mediated SMC (show DYM Antibodies) proliferation occurs through the involvement of Spm (show NPC1 Antibodies)-Cer (show CBLN1 Antibodies)-S1P (show MBTPS1 Antibodies) signaling axis under ANG II (show AGT Antibodies) stimulation of PASMCs
The expression patterns of MMP1 (show MMP1 Antibodies), MMP2, and MMP8 (show MMP8 Antibodies) were explored during fetal and postnatal development of longissimus dorsi muscle in cattle, and the relationships of MMP1 (show MMP1 Antibodies), MMP2, and MMP8 (show MMP8 Antibodies) expression levels with meat quality traits were analyzed in cattle. The expression of MMP1 (show MMP1 Antibodies), MMP2, and MMP8 (show MMP8 Antibodies) were also tested in four kinds of fat tissues and three kinds of skeletal muscle tissues.
The results showed that a decrease in MMP-1 (show MMP1 Antibodies) and MMP-2 gene expression is accompanied with a decrease in NO concentrations in infertile cows affected with ovarian cysts.
Activation of cytosolic MMP-9 (show MMP9 Antibodies) and MMP-2 was investigated in the retinal endothelial cells incubated in high glucose for 6-96 h, and correlated with their mitochondrial accumulation and mitochondrial damage.
Data indicate the involvement of PKC-alpha (show PKCa Antibodies) in proMMP-2 activation and inhibition of TIMP-2 (show TIMP2 Antibodies) expression by NF-kappaB (show NFKB1 Antibodies)-MT1-MMP (show MMP14 Antibodies)-dependent and -independent pathway.
Data suggest that EMMPRIN derived from endometrial epithelial cells regulates expression of matrix metalloproteinases (MMP-2; MMP-14 (show MMP14 Antibodies)) in endometrial stromal cells; expression of stromal MMPs is significantly higher in coculture with epithelial cells.
Adding pure bovine MMP-2 to the smooth muscle membrane suspension causes an increase in Ca(2+)-ATPase (show CA-P60A Antibodies) activity, but the pretreatment with TIMP-2 (show TIMP2 Antibodies) inhibits the increase in the enzyme activity
A differential pattern of matrix metalloproteinase-2 and Tissue inhibitor metalloproteinase-2 was observed in cow uteri with adenomyosis.
MMP-14 (show MMP14 Antibodies), MMP-2 and TIMP-2 (show TIMP2 Antibodies) are co-localized in the fetal compartment and therefore could influence the timely release of fetal membranes in cattle.
we demonstrated the presence of high molecular weight (HMW) complexes (130, 170, and 220 kDa) containing MMP9 (show MMP9 Antibodies), TIMP1 (show TIMP1 Antibodies), and NGAL (show LCN2 Antibodies) (also MMP2 in 220 kDa complex) without proteolytic activity.
Data demonstrate for the first time that MMP2 and MMP9 (show MMP9 Antibodies) are expressed in swine ovarian follicle both in theca and granulosa layers.
FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 (show MMP9 Antibodies) and MMP-2, caspase-3 (show CASP3 Antibodies) and BDNF (show BDNF Antibodies)
MMP-2 may play an important role in regulating MLC1 turnover in the heart under normal physiological conditions
Oxygen for newborn resuscitation increases MMP-2/-9 activity resulting in tissue damage and influencing remodeling processes.
PI3K-dependent regulation of MT1-MMP (show MMP14 Antibodies) protein synthesis and subsequent activation of latent MMP-2 as critical events in neointimal hyperplasia after vascular injury.
MMP-2 processes dental sialophosphoprotein into smaller subunits in the dentin matrix during odontogenesis
contribution of MMPs to the inflammatory breakdown of the blood-CSF (show CSF2 Antibodies) barrier in vitro
The levels of matrix metalloproteinase-2 and matrix metalloproteinase-9 (show MMP9 Antibodies) in the corpus luteum of swine during luteolysis are reported.
Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A (show VEGFA Antibodies), pro-MMP-9 (show MMP9 Antibodies), MMP-2, VEGFR-1 (show FLT1 Antibodies), VEGFR-2 (show KDR Antibodies), and TIMP-1 (show TIMP1 Antibodies), which may contribute to the development of venous stenosis.
Selenium suppressed high-fat diet-induced MMP2 over-expression in vivo by improving lipid metabolism.
Inflammatory factors such as TNF-alpha (show TNF Antibodies) can stimulate MMP-2/9 activity in corneal epithelium cells. This may be a potential manipulating mechanism of MMP expression in the pathogenesis of corneal diseases
Results provide evidence that MMP-2 bears the potentiality to cleave alpha-DG enriched from rabbit skeletal muscle indicating that this degradation indeed might also occur in vivo.
In conclusion, MMP-2 could be responsible for the proteolysis of dystrophin (show DMD Antibodies).
Castor (show CASZ1 Antibodies) oil polymer induces bone formation with high matrix metalloproteinase-2 expression.
MMP2 spinal cord expression is increased in cervical spondylotic myelopathy.
Ulinastatin (show AMBP Antibodies) effectively inhibited the increased expression of MMP-2, MMP-3 (show MMP3 Antibodies), and iNOS (show NOS2 Antibodies) in degenerated NP cells induced by IL-1beta (show IL1B Antibodies) in vitro.
Hemoperfusion could obviously reduce oxidative stress and the expression levels of MMP-2, MMP-9 (show MMP9 Antibodies) and TIMP-1 (show TIMP1 Antibodies) in rabbits with acute paraquat poisoning.
The RNA interference targeting COX-2 (show COX2 Antibodies) can effectively inhibit the expression of COX-2 (show COX2 Antibodies) and MMP-2 in IL-1alpha stimulated rabbit corneal stromal cells in vitro.
Our results strongly suggest that ischaemic postconditioning may exert part of its cardioprotective effects through the inhibition of MMP-2 activity.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene.
, matrix metalloprotease 2
, matrix metalloproteinase
, matrix metalloproteinase 2
, 72 kDa type IV collagenase
, Gelatinase A
, matrix metalloproteinase-2
, 72 kDa gelatinase
, gelatinase A
, 72kD gelatinase
, 72kD type IV collagenase
, 72kDa gelatinase
, 72kDa type IV collagenase
, collagenase type IV-A
, matrix metalloproteinase-II
, neutrophil gelatinase
, matrix metalloproteinase 2 (72 KDa type IV collagenase)
, matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)