MMP2 antibody (AA 40-280)

Catalog No. ABIN6143911

Product Details anti-MMP2 Antibody

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Binding Specificity: AA 40-280

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MMP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: DVAPKTDKEL AVQYLNTFYG CPKESCNLFV LKDTLKKMQK FFGLPQTGDL DQNTIETMRK PRCGNPDVAN YNFFPRKPKW DKNQITYRII GYTPDLDPET VDDAFARAFQ VWSDVTPLRF SRIHDGEADI MINFGRWEHG DGYPFDGKDG LLAHAFAPGT GVGGDSHFDD DELWTLGEGQ VVRVKYGNAD GEYCKFPFLF NGKEYNSCTD TGRSDGFLWC STTYNFEKDG KYGFCPHEAL F

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 40-280 of human MMP2 (NP_004521.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-MMP2 antibody (ABIN6143911)

Fu, Wang, Wu, Feng, Wang, Zhou, Ma, Wang: "HMGA1 exacerbates tumor growth through regulating the cell cycle and accelerates migration/invasion via targeting miR-221/222 in cervical cancer." in: Cell death & disease, Vol. 9, Issue 6, pp. 594, (2018) (PubMed).

Huang, Song, Sun, Zhang, Huang: "IRX5 promotes NF-κB signalling to increase proliferation, migration and invasion via OPN in tongue squamous cell carcinoma." in: Journal of cellular and molecular medicine, (2018) (PubMed).

Xing, Yu, Zhang, Luo, Lei, Huang, Lin, Huang, Huang, Nong, Zhou, Wei et al.: "Isoviolanthin Extracted from Dendrobium officinale Reverses TGF-β1-Mediated Epithelial⁻Mesenchymal Transition in Hepatocellular Carcinoma Cells via Deactivating the TGF-β/Smad and PI3K/Akt/mTOR ..." in: International journal of molecular sciences, Vol. 19, Issue 6, (2018) (PubMed).

"Retracted: 'Anti-fibrotic actions of Ghrelin by inhibition of the NADPH oxidase-ROS signaling pathway' by Qian Wang, Xin Sui, Rui Chen, Peiyong Ma, Tao Ding, Dianjun Sui, and Ping Yang." in: Clinical and experimental pharmacology & physiology, Vol. 45, Issue 8, pp. 885, (2018) (PubMed).

Wang, Dong, Liu, Xu, Hu, Fan, Chen: "Early growth response factor-1 DNA enzyme 1 inhibits the formation of abdominal aortic aneurysm in rats." in: Experimental and therapeutic medicine, Vol. 16, Issue 1, pp. 141-148, (2018) (PubMed).

Lee, Lee, Bu: "Protective Effects of Dihydrocaffeic Acid, a Coffee Component Metabolite, on a Focal Cerebral Ischemia Rat Model." in: Molecules (Basel, Switzerland), Vol. 20, Issue 7, pp. 11930-40, (2016) (PubMed).

Target Details for MMP2

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Alternative Name: MMP2 (MMP2 Products)

Synonyms: 2-MMP antibody, CG1794 antibody, DM2-MMP antibody, Dm2-MMP antibody, Dmel\\CG1794 antibody, MMP2 antibody, anon-WO0118547.84 antibody, dm-2MMP antibody, dmmp2 antibody, l(2)02353 antibody, mmp2 antibody, wu:fa99h12 antibody, wu:fk89d01 antibody, fgmmp-2 antibody, Mmp-2 antibody, LOC100135793 antibody, Clg4a antibody, GelA antibody, MMP-2 antibody, CLG4 antibody, CLG4A antibody, MMP-II antibody, MONA antibody, TBE-1 antibody, matrix metallopeptidase 2 antibody, Matrix metalloproteinase 2 antibody, matrix metalloproteinase 2 antibody, matrix metalloproteinase-2 antibody, MMP2 antibody, Mmp2 antibody, mmp2 antibody, LOC657982 antibody, LOC100135793 antibody

Background: This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.,CLG4,CLG4A,MMP-2,MMP-II,MONA,TBE-1,MMP2,Cancer,Tumor biomarkers,Invasion and Metastasis,Signal Transduction,G protein signaling,G2/M DNA Damage Checkpoint,Cell Biology & Developmental Biology,Extracellular Matrix,MMPs,Ubiquitin,Endocrine & Metabolism,Cardiovascular,Angiogenesis,Hypoxia,MMP2

Molecular Weight: 65 kDa/68 kDa/73 kDa

Gene ID: 4313

UniProt: P08253

Pathways: Activation of Innate immune Response