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Thyroid stimulating hormone activates CRTC2 via the TSHR (show TSHR Proteins)/cAMP/PKA pathway.
CRTC2 polymorphism as a risk factor for the incidence of metabolic syndrome in transplant recipients after solid organ transplantation.
CRTC2 strongly enhances GR-induced transcriptional activity of glucocorticoid-responsive genes.
Our results establish a role for CRTC2 as a lymphoma tumor suppressor gene
the high expression of CRTC2 and PROM1 may play an important role in the occurrence and hereditary, and also advance the potential pathways that integrate genetic variants in the development of NSCLC.
The data from the current study demonstrated novel PROM1 and CRTC2 mutations, which could promote lung cancer development.
These results clearly indicate that non-phosphorylated CRTC2 strongly enhances hepatitis b virus biosynthesis through inducing PGC1alpha expression.
Phosphorylation of CRTC2 at its AMPK (show PRKAA1 Proteins) target site, Ser (show SIGLEC1 Proteins) 171, dictated its subcellular localization, and the activation of aromatase (show CYP19A1 Proteins) PII in preadipocytes.
CRTC2 enhances CREB (show CREB1 Proteins) phosphorylation through an association with the protein arginine methyltransferase 5 (PRMT5 (show PRMT5 Proteins)).
Mechanism of CREB (show CREB1 Proteins) recognition and coactivation by the CREB (show CREB1 Proteins)-regulated transcriptional coactivator CRTC2
These results demonstrate how cross-coupling between the CREB (show CREB1 Proteins)/CRTC and JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) pathways contributes to bone marrow homeostasis.
the existence of an unusual functional interplay between STATs and CREB (show CREB1 Proteins) at the onset of adipogenesis through shared CRTC cofactors, is reported.
CRTC2 play a role in hepatic cholesterol synthesis through SREBP-2 (show SREBF2 Proteins).
Catecholaminergic deletion of Rictor increases water, sucrose, and morphine intake but not preference in a two-bottle choice assay in stress-naive mice, and these effects are maintained after stress. Ventral Tegmental Area-specific knockout of Rictor increases water and sucrose intake after physical CSDS, but does not alter consummatory behavior in the absence of stress.
Three mouse CRTCs (Crtc1 (show CRTC1 Proteins), Crtc2 and Crtc3 (show CRTC3 Proteins)) exhibit distinct patterns of 14-3-3 (show YWHAQ Proteins) binding at three conserved sites corresponding to S70, S171 (show NUMB Proteins), and S275 (in CRTC2).
the protein expression of adipose tissue CRTC 2 was reduced in mice with a combined application of change to general diet and exercise. In addition, while the protein expressions of lipase (show LIPG Proteins) ATGL (show PNPLA2 Proteins) and HSL (show LIPE Proteins) were reduced in the mice fed with the high fat diet continually after obesity was induced
CRTC2 promotes Th17 cell differentiation via stimulation of IL-17A (show IL17A Proteins) and IL-17F (show IL17F Proteins) expression by binding to CREB (show CREB1 Proteins) over both promoters. CRTC2-mutant mice have decreased Th17 cells, and they are protected from experimental autoimmune encephalitis.
chronic increases in CRTC2 activity in the liver are indeed sufficient to promote hepatic insulin (show INS Proteins) resistance and to disrupt glucose homeostasis
cAMP, SIK and CRTC mediate StAR expression through activation of individual StAR gene loci.
This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5.
CREB regulated transcription coactivator 2
, CREB-regulated transcription coactivator 2
, CREB-regulated transcription coactivator 2-like
, transducer of regulated cAMP response element-binding protein (CREB) 2
, transducer of CREB protein 2
, transducer of regulated cAMP response element-binding protein 2