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anti-Human PRKAA2 Antibodies:
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Cow (Bovine) Polyclonal PRKAA2 Primary Antibody for WB - ABIN151705
Rubin, Magliola, Feng, Jones, Hale: Metabolic activation of AMP kinase in vascular smooth muscle. in Journal of applied physiology (Bethesda, Md. : 1985) 2004
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Human Polyclonal PRKAA2 Primary Antibody for IF (p), IHC (p) - ABIN680458
Fu, Zhu, Dodson, Du: AMP-activated protein kinase stimulates Warburg-like glycolysis and activation of satellite cells during muscle regeneration. in The Journal of biological chemistry 2015
Show all 2 Pubmed References
Human Polyclonal PRKAA2 Primary Antibody for ELISA, EIA - ABIN4280438
Dong, Zhang, Liang, Xie, Zhao, Asfa, Choi, Zou: Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivo. in Circulation 2010
Cow (Bovine) Polyclonal PRKAA2 Primary Antibody for IP - ABIN153316
Gusarova, Dada, Kelly, Brodie, Witters, Chandel, Sznajder: Alpha1-AMP-activated protein kinase regulates hypoxia-induced Na,K-ATPase endocytosis via direct phosphorylation of protein kinase C zeta. in Molecular and cellular biology 2009
PRKAA2 Polymorphisms in rs10789038 and rs2796498 are associated with the susceptibility to type 2 diabetes mellitus and diabetic nephropathy.
Lack of mitochondrial DNA impairs chemical hypoxia-induced autophagy in liver tumor cells through reactive oxygen species-AMPK (show PRKAA1 Antibodies)-ULK1 (show ULK1 Antibodies) signaling dysregulation independently of HIF-1A (show HIF1A Antibodies).
PRKAA deletion promoted mitochondrial fragmentation in vascular endothelial cells by inhibiting the autophagy-dependent degradation of DNM1L (show DNM1L Antibodies).
AMPK phosphorylates DNMT1, RBBP7, and HAT1 and increases interactions of DNMT1, RBBP7, and HAT1.
PGC-1alpha protein was higher after HIHVT than after SIT (p < 0.05). Moreover, the AMPKpTHR172/AMPK (show PRKAA1 Antibodies) ratio increased at post after SIT (p < 0.05), whereas this effect was delayed after HIHVT as it increased after 3 h
TNF-alpha (show TNF Antibodies) treatment of colonic rho(0) cells augmented IL-8 (show IL8 Antibodies) expression by 9-fold (P < 0.01) via NF-kappaB (show NFKB1 Antibodies) compared to TNF-alpha (show TNF Antibodies)-treated control. Moreover, reduced mitochondrial function facilitated TNF-alpha (show TNF Antibodies)-mediated NF-kappaB (show NFKB1 Antibodies) luciferase promoter activity as a result of lowered inhibitory IkappaBalpha (show NFKBIA Antibodies) (nuclear factor of kappa light polypeptide gene enhancer in B-cell inhibitor, alpha), leading to elevated NF-kappaB (show NFKB1 Antibodies). ...
Results highlight the contribution of AMPKalpha2 as a mechanism for controlling bladder cancer growth by regulating proliferation through mTOR (show FRAP1 Antibodies) suppression and induction of p27 (show PAK2 Antibodies) protein levels, thus indicating how AMPKalpha2 loss may contribute to tumorigenesis.
AMPK (show PRKAA1 Antibodies) phosphorylation of cortactin (show CTTN Antibodies) followed by SIRT1 (show SIRT1 Antibodies) deacetylation modulates the interaction of cortactin (show CTTN Antibodies) and cortical-actin in response to shear stress. Functionally, this AMPK (show PRKAA1 Antibodies)/SIRT1 (show SIRT1 Antibodies) coregulated cortactin (show CTTN Antibodies)-F-actin dynamics is required for endothelial nitric oxide synthase (show NOS3 Antibodies) subcellular translocation/activation and is atheroprotective.
Data suggest that the AMPK (show PRKAA1 Antibodies)-TBC1D4 (show TBC1D4 Antibodies) signaling axis is likely mediating the improved muscle insulin (show INS Antibodies) sensitivity after contraction/exercise and illuminates an important and physiologically relevant role of AMPK (show PRKAA1 Antibodies) in skeletal muscle.
inactivation of AMPKalpha2, but not AMPKalpha1 (show PRKAA1 Antibodies), abrogates the tumor attenuation caused by UBE2O (show UBE2O Antibodies) loss.
Study indicate that the alpha 2 and alpha 1 subunits of AMPK (show PRKAA1 Antibodies) have several functional differences, with alpha 2 conferring stronger osteogenic potential and a weaker ability to induce osteoblasts-associated osteoclastogenesis in MC3T3-E1 cells as well as conferring a lower adipogenic potential to 3T3-L1 cells.
activation of AMPK (show PRKAA1 Antibodies) at early stage of adipogenesis is involved in the anti-adipogenesis effect of Red Pepper Seed extract.
data suggest that AMPK (show PRKAA1 Antibodies) is an intermediate effector in endocannabinoid-mediated exercise-induced antinociception.
The rs2746342 polymorphism is significantly associated with susceptibility to type 2 diabetes mellitus (T2DM) and seems to interact with the rs2143754 polymorphism in the modulation of fasting plasma glucose (FPG) in the Han Chinese population.
AMPKalpha2 activation prevents cardiac hypertrophy predominantly by inhibiting O-GlcNAcylation.
Ampk (show PRKAA1 Antibodies) is required for exercise-induced mitophagy in muscle.
This novel mechanism explains how CDK4 (show CDK4 Antibodies) promotes anabolism by blocking catabolic processes (FAO) that are activated by AMPK (show PRKAA1 Antibodies).
High AMPKalpha2 phosphorylation is associated with abdominal aortic aneurysm.
Single SNP and haplotype analyses revealed weak associations between the PRKAA2 genotypes and loin muscle area in the investigated populations.
Endometrial inflammatory responses to lipopolysaccharide were also reduced by small molecules that activate or inhibit the intracellular sensor of energy, AMP-activated protein kinase (AMPK).
The investigation of PRKAA2 genetic polymorphisms in three Chinese indigenous bovine breeds [Qinchuan (n = 328), Nanyang (n = 278), Jiaxian (n = 148)] and yak (n = 57), is reported.
These data show that the AMPK (show PRKAA1 Antibodies) activator AICAR (show ATIC Antibodies) is inhibitory to nuclear maturation in bovine oocytes due to activation of AMPK (show PRKAA1 Antibodies) [AMP-activated protein kinase alpha (show PAK1 Antibodies) 1 subunit].
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
5'-AMP-activated protein kinase catalytic subunit alpha-2
, 5'-AMP-activated protein kinase, catalytic alpha-2 chain
, ACACA kinase
, AMPK subunit alpha-2
, AMPK-alpha-2 chain
, HMGCR kinase
, acetyl-CoA carboxylase kinase
, hydroxymethylglutaryl-CoA reductase kinase
, AMP-activated protein kinase
, AMPK alpha-2 chain
, AMP-activated protein kinase alpha-2 variant B
, AMP-activated protein kinase alpha 2
, protein kinase AMP-activated alpha 2 catalytic subunit
, SNF1-like protein AMPK
, 5'-AMP-activated protein kinase alpha-2 catalytic subunit
, AMP-activated protein kinase alpha 2 catalytic subunit
, protein kinase, AMP-activated, alpha 2 catalytic subunit
, AMPK-activated protein kinase alpha-2 subunit