SARS-CoV-2 Spike S2 antibody (C-Term)

Details for Product anti-SARS-CoV-2 Spike S2 Antibody No. ABIN1030641
Antigen
  • E2
  • Surface Glycoprotein
  • S
Epitope
C-Term
9
Reactivity
SARS Coronavirus (SARS-CoV), SARS Coronavirus-2 (SARS-CoV-2)
11
Host
Rabbit
7
4
Clonality
Polyclonal
Conjugate
This SARS-CoV-2 Spike S2 antibody is un-conjugated
3
2
Application
ELISA, Immunofluorescence (IF), Western Blotting (WB)
11
9
7
Options
Immunogen Anti-SARS-CoV-2 (COVID-19, 2019-nCoV) Spike antibody was raised against a peptide corresponding to 20 amino acids near the carboxy terminus of SARS-CoV-2 (COVID-19, 2019-nCoV) Spike glycoprotein.
The immunogen is located within the last 50 amino acids of SARS-CoV-2 (COVID-19, 2019-nCoV) Spike protein.
Blocking Peptide Blocking peptide for this product available: ABIN1382273
Isotype IgG
Predicted Reactivity Predicted reactivity based on immunogen sequence: SARS-CoV Spike proteins: (100%)
Purification Affinity chromatography purified via peptide column
Antigen
Background Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus. The disease is the cause of the 2019–20 coronavirus outbreak. The structure of 2019-nCoV consists of the following: a Spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. Coronavirus invades cells through Spike (S) glycoproteins, a class I fusion protein. It is the major viral surface protein that coronavirus uses to bind to the human cell surface receptor. It also mediates the fusion of host and viral cell membrane, allowing the virus to enter human cells and begin infection. The spike protein is the major target for neutralizing antibodies and vaccine development. The protein modeling suggests that there is strong interaction between Spike protein receptor-binding domain and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of COVID-19. The recent study has shown that the SARS-CoV-2 spike protein binds ACE2 with higher affinity than SARS-CoV spike protein .
NCBI Accession QHD43416
Application Notes SARS-CoV-2 (COVID-19, 2019-nCoV) Spike antibody can be used for the detection of SARS-CoV-2 (COVID-19, 2019-nCoV) Spike protein in ELISA. It will detect 4 ng of free peptide at 1 μg/mL.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer The antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Storage 4 °C/-20 °C
Storage Comment Antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Expiry Date 12 months
Supplier Images
Image no. 1 for anti-SARS-CoV-2 Spike S2 (C-Term) antibody (ABIN1030641) ELISA Test Antibodies: SARS-CoV-2 (COVID-19, 2019-nCoV) Spike antibody, ABIN1030641 (...
Product cited in: Magro, Mulvey, Berlin, Nuovo, Salvatore, Harp, Baxter-Stoltzfus, Laurence: "Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases." in: Translational research : the journal of laboratory and clinical medicine, Vol. 220, pp. 1-13, 2020 (PubMed).

Mulvey, Magro, Ma, Nuovo, Baergen: "Analysis of complement deposition and viral RNA in placentas of COVID-19 patients." in: Annals of diagnostic pathology, Vol. 46, pp. 151530, 2020 (PubMed).

Jan Pietschmann, Nadja Vöpel, Holger Spiegel, Hans-Joachim Krause, Florian Schröper: "Brief Communication: Magnetic Immuno-Detection of SARS-CoV-2 specific Antibodies" in: bioRxiv, 2020

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