PLAP antibody

Catalog No. ABIN1105297

This Mouse Monoclonal antibody specifically detects PLAP in IHC (fro) and EIA. It exhibits reactivity toward Tag.

Quick Overview for PLAP antibody (ABIN1105297)

Target: PLAP (ALPP) (Placental Alkaline Phosphatase (ALPP))

Reactivity: Tag

Host: Mouse

Clonality: Monoclonal

Conjugate: This PLAP antibody is un-conjugated

Application: Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Clone: V17-1

Product Details anti-PLAP Antibody

Specificity: This antibody clone V17.1 reacts with alkaline phosphatase, an enzym widely used in immunodection tests. Can be used for detection of Alkaline Phophatase and for amplification of Alkaline Phophatase reactions (APAP).

Purification: Purified

Immunogen: A BALB/c Mouse was immunized with Alkaline Phophatase.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 0.05 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or -20 °C for longer.

Target Details for PLAP

Target: PLAP (ALPP) (Placental Alkaline Phosphatase (ALPP))

Target Type: Tag

Background: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.Synonyms: Alkaline phosphatase, Alkaline phosphatase Regan isozyme, PLAP-1, placental type

Gene ID: 250

NCBI Accession: NP_001623

UniProt: P05187