Carboxy Methyl Lysine antibody

Catalog No. ABIN1105660

This Mouse Monoclonal antibody specifically detects Carboxy Methyl Lysine in EIA, WB, IHC (fro), IF and IHC (p). It exhibits reactivity toward .

Quick Overview for Carboxy Methyl Lysine antibody (ABIN1105660)

Target: Carboxy Methyl Lysine (CML)

Host: Mouse

Clonality: Monoclonal

Conjugate: This Carboxy Methyl Lysine antibody is un-conjugated

Application: Enzyme Immunoassay (EIA), Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CML26

Product Details anti-Carboxy Methyl Lysine Antibody

Cross-Reactivity (Details): Species reactivity (tested):Human, Multispecies cross reactant.

Purification: Protein G Chromatography

Immunogen: Carboxy Methyl Lysine (CML)-KLH

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 0.02 % Sodium Azide, 0.1 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 2-8 °C.

Target Details for Carboxy Methyl Lysine

Target: Carboxy Methyl Lysine (CML)

Alternative Name: Carboxy Methyl Lysine

Target Type: Amino Acid

Background: CML is known to be formed from the oxidation of both carbohydrates and lipids. This makes CML a biomarker of general oxidative stress. Carboxymethyl-lysine (CML) is a well-characterized glycoxidation product that accumulates in tissues with age, and its rate of accumulation is accelerated in diabetes. Glycoxidation products are a subset of advanced glycation endproducts (AGEs) that are formed by the nonenzymatic glycation and subsequent irreversible oxidation of proteins. Oxidative stress and protein modification have been implicated in the pathogenesis of the chronic complications of diabetes, including nephropathy and atherosclerosis. The accumulation of CML in long-lived tissue such as skin collagen reflects oxidative stress over an extended period of the life-span, and has been shown to be greater in patients with diabetic complications than those without complications.Synonyms: CML, Carboxymethyl-lysine