C9 antibody

Catalog No. ABIN1106797

This Mouse Monoclonal antibody specifically detects C9 in IHC (p), IF, EIA, IHC (fro) and Func. It exhibits reactivity toward Human, Horse and Pig.

Quick Overview for C9 antibody (ABIN1106797)

Target: C9 (Complement Component C9 (C9))

Reactivity: Human, Horse, Pig

Host: Mouse

Clonality: Monoclonal

Conjugate: This C9 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

Clone: AE11

Product Details anti-C9 Antibody

Cross-Reactivity (Details): Species reactivity (tested):Human, Horse, Swine.

Purification: Protein G Chromatography

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA

Storage: 4 °C

Storage Comment: Store undiluted at 2-8 °C.

Target Details for C9

Target: C9 (Complement Component C9 (C9))

Alternative Name: Complement C9

Background: The three distinct activation pathways of complement converge with the formation of a C5 convertase. The cleavage of C5 by this convertase initiates the lytic or terminal pathway. In contrast to the activation pathways, which require enzymatic cleavage for activation, the terminal pathway relies on conformational changes induced by binding. Binding of C6 facilitates binding of C7 which alters the conformation of the complex. After binding of C8, a variable number of C9 Molecules associate with the C5b678 complex, which is also termed the terminal complement complex (TCC). The formation of TCC causes lysis of cells or can trigger a variety of cellular metabolic pathways resulting in the synthesis and release of inflammatory mediators. The TCC contains neoantigens that are absent from the individual native components. C9 neoantigens are present both in the membrane-bound (MAC) and the fluid-phase (SC5b-9) complex. TCC is present in normal human plasma and increased in patients with complement activation.Synonyms: Complement 9, Complement component C9

UniProt: P02748

Pathways: Complement System