Desmoplakin antibody

Catalog No. ABIN1106984

The Rabbit Polyclonal anti-Desmoplakin antibody is suitable to detect Desmoplakin in samples from Human. It has been validated for WB, IHC (fro) and EIA.

Quick Overview for Desmoplakin antibody (ABIN1106984)

Target: Desmoplakin (DSP)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Desmoplakin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Product Details anti-Desmoplakin Antibody

Specificity: Reacts with Human 331 kDa Desmoplakin.

Purification: Affinity Chromatography on Protein A

Immunogen: Synthetic peptide derived from an internal domain of Human DP

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Restore in distilled water.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Prior to reconstitution store the antibody at -20 °C. Store reconstituted antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer

Target Details for Desmoplakin

Target: Desmoplakin (DSP)

Alternative Name: Desmoplakin

Background: Desmoplakin is an obligate component of functional desmosomes that attaches intermediate filaments to desmosomal plaques. It is involved in the organization of desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains. The N-terminus of desmoplakin is essential for localisation to the desmosome and interaction with plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds to intermediate filaments. The central region of desmoplakin comprises a coiled-coil rod domain that mediates homodimerisation. There are two isoforms of desmoplakin - desmoplakin I, which is an obligate component of all desmosomes, and desmoplakin II, which is predominantly expressed in tissues and cells of stratified origin. Mutations in the gene encoding desmoplakin result in a number of cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.Synonyms: 250/210 kDa paraneoplastic pemphigus antigen, DP, DSP

Gene ID: 1832

NCBI Accession: NP_001008844

Pathways: Cell-Cell Junction Organization