HTRA2 antibody

Catalog No. ABIN1107619

This Mouse Monoclonal antibody specifically detects HTRA2 in WB, IP and IHC (p). It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for HTRA2 antibody (ABIN1107619)

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HTRA2 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 18-01-83

Product Details anti-HTRA2 Antibody

Specificity: This antibody reacts with HtrA2/Omi (40 kDa) on Western blotting.

Purification: Protein-A Agarose Chromatography of hybridoma supernatant.

Immunogen: Human recombinant 6His tagged HtrA2/Omi.

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.2 containing 50 % Glycerol without preservatives.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

References for anti-HTRA2 antibody (ABIN1107619)

Chung, Islam, Rahman, Hong: "Neuroprotective function of Omi to α-synuclein-induced neurotoxicity." in: Neurobiology of disease, Vol. 136, pp. 104706, (2021) (PubMed).

Target Details for HTRA2

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Alternative Name: HTRA2 / PRSS25

Background: HtrA2, also known as Omi or Serine Protease-25, is a trimeric chaperone/heat shock protein involved in the degradation of aberrantly folded proteins during cellular stress. The ubiquitous HtrA2 protein exists as two isoforms of 38 and 40 kDa and as an alternatively spliced form called D-Omi, which is predominately expressed in the kidney, colon and thyroid. HtrA2 appears to function in the progression of arthritis, aging, and tumor progression. During apoptosis, HtrA2 is released from mitochondria into the cytoplasm where it inhibits XIAP, a caspase inhibitor. Release of HtrA2 from mitochondria appears to require Bax and Bcl-2, and the resulting overexpression of HtrA2 into the cytoplasm induces caspase-independent apoptosis.Synonyms: High temperature requirement protein A2, OMI, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI, mitochondrial Serine protease HTRA2

Gene ID: 27429

NCBI Accession: NP_037379

UniProt: O43464

Pathways: Positive Regulation of Endopeptidase Activity