HTRA2 antibody
(1 reference)-
- Target See all HTRA2 Antibodies
- HTRA2 (HtrA Serine Peptidase 2 (HTRA2))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This HTRA2 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)
- Specificity
- This antibody reacts with HtrA2/Omi (40 kDa) on Western blotting.
- Purification
- Protein-A Agarose Chromatography of hybridoma supernatant.
- Immunogen
- Human recombinant 6His tagged HtrA2/Omi.
- Clone
- 18-01-83
- Isotype
- IgG2a
- Top Product
- Discover our top product HTRA2 Primary Antibody
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anti-HtrA Serine Peptidase 2 (HTRA2) (AA 278-458) antibody
HTRA2 Reactivity: Human WB, ELISA, IHC, FACS Host: Mouse Monoclonal 6H7A8 unconjugated
anti-HtrA Serine Peptidase 2 (HTRA2) (AA 334-458) antibodyHTRA2 Reactivity: Human WB, ELISA, IHC, IP Host: Rabbit Polyclonal unconjugated
anti-HtrA Serine Peptidase 2 (HTRA2) (AA 359-458) antibodyHTRA2 Reactivity: Human WB, ELISA, IF Host: Mouse Monoclonal 4F10 unconjugated
anti-HtrA Serine Peptidase 2 (HTRA2) (AA 73-102), (N-Term) antibodyHTRA2 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB33645 unconjugated
anti-HtrA Serine Peptidase 2 (HTRA2) (AA 231-330) antibodyHTRA2 Reactivity: Human, Mouse, Rat WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC Host: Rabbit Polyclonal unconjugated
anti-HtrA Serine Peptidase 2 (HTRA2) antibodyHTRA2 Reactivity: Human WB, IP Host: Mouse Monoclonal 8G11-4B8-4F10-G5 unconjugated
anti-HtrA Serine Peptidase 2 (HTRA2) (AA 335-350) antibodyHTRA2 Reactivity: Human WB, IHC Host: Mouse Monoclonal 196C429 unconjugated
anti-HtrA Serine Peptidase 2 (HTRA2) antibodyHTRA2 Reactivity: Human, Mouse, Rat WB, IHC, IF, IC Host: Rabbit Polyclonal unconjugated
anti-HtrA Serine Peptidase 2 (HTRA2) antibodyHTRA2 Reactivity: Human, Mouse WB, ELISA Host: Mouse Monoclonal 1B3 unconjugated
anti-HtrA Serine Peptidase 2 (HTRA2) (AA 134-458) antibodyHTRA2 Reactivity: Human WB, ELISA Host: Mouse Monoclonal 1B3 unconjugated
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS, pH 7.2 containing 50 % Glycerol without preservatives.
- Preservative
- Without preservative
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- -20 °C
- Storage Comment
- Store the antibody (in aliquots) at -20 °C.
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: "Neuroprotective function of Omi to α-synuclein-induced neurotoxicity." in: Neurobiology of disease, Vol. 136, pp. 104706, (2021) (PubMed).
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: "Neuroprotective function of Omi to α-synuclein-induced neurotoxicity." in: Neurobiology of disease, Vol. 136, pp. 104706, (2021) (PubMed).
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- Target
- HTRA2 (HtrA Serine Peptidase 2 (HTRA2))
- Alternative Name
- HTRA2 / PRSS25 (HTRA2 Products)
- Background
- HtrA2, also known as Omi or Serine Protease-25, is a trimeric chaperone/heat shock protein involved in the degradation of aberrantly folded proteins during cellular stress. The ubiquitous HtrA2 protein exists as two isoforms of 38 and 40 kDa and as an alternatively spliced form called D-Omi, which is predominately expressed in the kidney, colon and thyroid. HtrA2 appears to function in the progression of arthritis, aging, and tumor progression. During apoptosis, HtrA2 is released from mitochondria into the cytoplasm where it inhibits XIAP, a caspase inhibitor. Release of HtrA2 from mitochondria appears to require Bax and Bcl-2, and the resulting overexpression of HtrA2 into the cytoplasm induces caspase-independent apoptosis.Synonyms: High temperature requirement protein A2, OMI, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI, mitochondrial Serine protease HTRA2
- Gene ID
- 27429
- NCBI Accession
- NP_037379
- UniProt
- O43464
- Pathways
- Positive Regulation of Endopeptidase Activity
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