IL23A antibody

Catalog No. ABIN1107827

The Mouse Monoclonal anti-IL23A antibody has been validated for IHC (p) and Func. It is suitable to detect IL23A in samples from Human.

Quick Overview for IL23A antibody (ABIN1107827)

Target: IL23A (Interleukin 23, alpha subunit p19 (IL23A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL23A antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Functional Studies (Func)

Clone: B-Z23

Product Details anti-IL23A Antibody

Specificity: This antibody recognizes both recombinant and natural IL-23, p19 sub-unit.

Purification: Ion Exchange Chromatography

Sterility: 0.22 μm filtered

Immunogen: Recombinant Human IL-23 (sub-unit p19)

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate-buffered saline. Sterile-filtered through 0.22 μm and treated to remove endotoxins. Carrier and preservative free.

Preservative: Without preservative

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for IL23A

Target: IL23A (Interleukin 23, alpha subunit p19 (IL23A))

Alternative Name: Interleukin-23 alpha / IL23A

Background: The p19 shares sequence similarity with IL-6 subfamily members and is distantly related to the p35 subunit of IL-12. It shows no biological activity by itself, instead, it combines with the p40 subunit of IL-12 to form a biologically active, composite cytokine, IL-23. IL-23 shares some in vivo functions with IL-12, including the activation of the transcription factor Stat4. Similar to IL-12, human IL-23 stimulates IFN-g production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death.Synonyms: IL-23 subunit alpha, IL-23p19, Interleukin-23 subunit p19, SGRF

Gene ID: 51561

NCBI Accession: NP_057668

UniProt: Q9NPF7

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation