MIER1 antibody (Middle Region)

Catalog No. ABIN1108246

This Rabbit Polyclonal antibody specifically detects MIER1 in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Zebrafish (Danio rerio), Cow, Rabbit, Chicken and Xenopus laevis.

Quick Overview for MIER1 antibody (Middle Region) (ABIN1108246)

Target: MIER1 (Mesoderm Induction Early Response 1 (MIER1))

Reactivity: Human, Mouse, Rat, Dog, Zebrafish (Danio rerio), Cow, Rabbit, Chicken, Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MIER1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MIER1 Antibody

Binding Specificity: Middle Region

Sequence: RRTGDEKGVE AIPEGSHIKD NEQALYELVK CNFDTEEALR RLRF

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat, Dog, Zebrafish, African clawed frog, Chicken, Bovine, RabbitSpecies reactivity (tested):Human

Purification: Purified using Protein A affinity column

Immunogen: The immunogen for anti-MIER1 antibody: synthetic peptide directed towards the middle region of human MIER1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Add 100 μL of distilled water to a final concentration of 1 mg/mL.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Target Details for MIER1

Target: MIER1 (Mesoderm Induction Early Response 1 (MIER1))

Alternative Name: MIER1

Background: The association of hMI-ER1 with Sp1 represents a novel mechanism for the negative regulation of Sp1 target promoters. Results demonstrate that alternate use of a facultative intron regulates the subcellular localization of hMI-ER1 proteins and this may have important implications for hMI-ER1 function in the regulation of transcription. Repressor activity is due to interaction and recruitment of a trichostatin A-sensitive histone deacetylase 1 (HDAC1).Synonyms: Early response 1, Er1, KIAA1610, Mesoderm induction early response protein 1, Mi-er1, hmi-er1

Gene ID: 57708

NCBI Accession: NP_065999

Pathways: Chromatin Binding