PLGF antibody (N-Term)

Catalog No. ABIN1108665

This anti-PLGF antibody is a Rabbit Polyclonal antibody detecting PLGF in WB, IHC (p) and IF. Suitable for Human, Mouse and Rat.

Quick Overview for PLGF antibody (N-Term) (ABIN1108665)

Target: PLGF (PGF) (Placenta Growth Factor (PGF))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLGF antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-PLGF Antibody

Binding Specificity: N-Term

Specificity: This antibody detects Placenta growth factor / PGF (N-term). No cross reactivity with other proteins.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat.

Purification: Immunogen affinity purified

Immunogen: Synthetic peptide corresponding to a sequence mapping near the N-terminal of human PLGF .Remarks: Sequence is different from the related rat sequence by two different amino acids.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: 1.2 % sodium acetate or neutral PBS. If 0.5 mL of PBS is used, the antibody concentration will be 100 μg/mL.

Buffer: 50 % glycerol, 0.9 mg NaCl, 0.2 mg Na2HPO4

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for PLGF

Target: PLGF (PGF) (Placenta Growth Factor (PGF))

Alternative Name: Placenta Growth Factor / PGF

Background: Placental growth factor (PGF, also known as PLGF) codes for an angiogenic factor expressed in placental tissue that is similar to vascular permeability factor/vascular endothelial growth factor (VPF/VEGF). It is a glycosylated dimeric secreted protein able to stimulate endothelial cell growth in vitro. PGF is located on chromosome 14 and has been conserved in evolution. It belongs to the family of vascular endothelial growth factors (VEGFs) and binds to the flt-1 VEGF receptor. PLGF-2, which is a PLGF isoform, binds neuropilin-1 and 2 in a heparin-dependent manner. PGF regulates inter-and intra molecular cross talk between the VEGF RTKs Flt1 and Flk1 and stimulates the phosphorylation of specific Flt1 tyrosine residues and the expression of distinct downstream target genes. Moreover, it plays an important role in pathological angiogenic events and with exerting its biological activities through binding to VEGFR1.Synonyms: PGFL, PLGF, PlGF

Gene ID: 5228

NCBI Accession: NP_002623

UniProt: P49763

Pathways: VEGFR1 Specific Signals