PROS1 antibody (FITC)
Quick Overview for PROS1 antibody (FITC) (ABIN1108757)
Target
See all PROS1 (PROS) AntibodiesReactivity
Host
Clonality
Conjugate
Application
Clone
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Cross-Reactivity (Details)
- Species reactivity (tested):Human.
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Purification
- Protein G Chromatography
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Isotype
- IgG2a
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Concentration
- 0.1 mg/mL
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Buffer
- PBS, 0.02 % Sodium Azide, 1 % BSA
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Preservative
- Sodium azide
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Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C
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Storage Comment
- Store undiluted at 2-8 °C.
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- PROS1 (PROS) (Protein S (PROS))
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Background
- In humans, PS is mainly synthesized by hepatocytes. Mature PS has a modular structure consisting of a Gla-domain containing a short aromatic stack, a region sensitive to cleavage by thrombin and factor Xa , 4 epidermal growth factor (EGF)-like domains, and a sex hormone-binding globulin-like region. The biologic function of PS thought to be of primary importance is its ability to enhance Activated Protein C-dependent proteolytic inactivation of factors Va and VIIIa, which are respectively the cofactors in the pro-thrombinase and tenase complexes of the coagulation cascade. In this way, PS plays an important role in regulating thrombin generation, and therefore controlling procoagulant activity. Crucial to the APC-dependent functions of PS is the high-affinity interaction between PS and negatively charged phospholipid surfaces, conferred by calcium-induced folding of the amino-terminal Gla-domain.Synonyms: PROS, Vitamin K-dependent protein S
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UniProt
- P07225
Target
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