RUNX1T1 antibody (Middle Region)

Catalog No. ABIN1108915

Product Details anti-RUNX1T1 Antibody

Target: RUNX1T1 (Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Zebrafish (Danio rerio), Chicken, Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RUNX1T1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LHSEHPSKRP CTISPGQRYS PNNGLSYQPN GLPHPTPPPP QHYRLDDMAI

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat, Dog, ZebraFish, Chicken, African clawed frogSpecies reactivity (tested):Human

Purification: Purified using Protein A affinity column

Immunogen: The immunogen for anti-RUNX1T1 antibody: synthetic peptide directed towards the middle region of human RUNX1T1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Add 100 μL of distilled water to a final concentration of 1 mg/mL.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Target Details for RUNX1T1

Target: RUNX1T1 (Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1))

Alternative Name: RUNX1T1 (RUNX1T1 Products)

Background: RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation.Synonyms: AML1T1, CBFA2T1, CDR, Cyclin-D-related protein, ETO, Eight twenty one protein, MTG8, ZMYND2, Zinc finger MYND domain-containing protein 2

Gene ID: 862

NCBI Accession: NP_783554