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RUNX1T1 antibody (Internal Region)

RUNX1T1 Reactivity: Human IP, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6971634
$605.00
Plus shipping costs $45.00
100 μL
Shipping to: United States
Delivery in 5 to 7 Business Days
  • Target See all RUNX1T1 Antibodies
    RUNX1T1 (Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1))
    Binding Specificity
    • 7
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 38
    • 21
    • 11
    • 8
    • 7
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    Human
    Host
    • 34
    • 4
    Rabbit
    Clonality
    • 36
    • 2
    Polyclonal
    Conjugate
    • 27
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RUNX1T1 antibody is un-conjugated
    Application
    • 22
    • 15
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    Immunoprecipitation (IP), Western Blotting (WB)
    Characteristics
    ETO / RUNX1T1 (AML1T1, CBFA2T1, MTG8, ZMYND2) belongs to a family of evolutionarily conserved nuclear factors that act as a transcriptional corepressor. ETO / RUNX1T1 does not interact directly with DNA but is recruited by transcription factors such as PLZF, BCL6, TAL1/SCL, Gfi1and Heb recruit nuclear co-repressors such as NCoR, SIN3, and SMRT / NCoR2, which in turn interact with histone deacetylase (HDAC) to mediate transcriptional repression. ETO / RUNX1T1 contains four evolutionarily conserved functional domains called nervy homology regions (NHRs) involved in protein-protein interaction. ETO / RUNX1T1 is frequently found as a fusion partner of AML1 in acute myeloid leukemia with the t(8,21) translocation which gives rise to the AML-ETO fusion protein. ETO / RUNX1T1 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Immunoprecipitation and Western blot, it has been shown to react with Human samples.
    Purification
    Affinity Purified
    Immunogen
    This ETO / RUNX1T1 antibody was raised against a peptide within the internal region of human ETO / RUNX1T1.
    Isotype
    IgG
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
  • Target
    RUNX1T1 (Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1))
    Alternative Name
    ETO / RUNX1T1 (RUNX1T1 Products)
    Synonyms
    MTG8, si:ch211-232j17.1, wu:fi14b07, zgc:154044, AML1T1, CBFA2T1, CDR, ETO, ZMYND2, Cbfa2t1h, Cbfa2t1, runt-related transcription factor 1; translocated to, 1 (cyclin D-related), RUNX1 translocation partner 1 L homeolog, RUNX1 translocation partner 1, runx1t1, runx1t1.L, RUNX1T1, Runx1t1
    Background
    ETO / RUNX1T1 (AML1T1, CBFA2T1, MTG8, ZMYND2) belongs to a family of evolutionarily conserved nuclear factors that act as a transcriptional corepressor. ETO / RUNX1T1 does not interact directly with DNA but is recruited by transcription factors such as PLZF, BCL6, TAL1/SCL, Gfi1and Heb recruit nuclear co-repressors such as NCoR, SIN3, and SMRT / NCoR2, which in turn interact with histone deacetylase (HDAC) to mediate transcriptional repression. ETO / RUNX1T1 contains four evolutionarily conserved functional domains called nervy homology regions (NHRs) involved in protein-protein interaction. ETO / RUNX1T1 is frequently found as a fusion partner of AML1 in acute myeloid leukemia with the t(8,21) translocation which gives rise to the AML-ETO fusion protein.
    Molecular Weight
    68 kDa
    NCBI Accession
    NP_783553
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