SHOX2 antibody (Middle Region)

Catalog No. ABIN1109006

Product Details anti-SHOX2 Antibody

Target: SHOX2 (Short Stature Homeobox 2 (SHOX2))

Binding Specificity: Middle Region

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SHOX2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SEARVQVWFQ NRRAKCRKQE NQLHKGVLIG AASQFEACRV APYVNVGALR

Cross-Reactivity (Details): Species reactivity (expected):Mouse, RatSpecies reactivity (tested):Human

Purification: Purified using peptide immunoaffinity column

Immunogen: The immunogen for anti-SHOX2 antibody: synthetic peptide directed towards the middle region of human SHOX2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Target Details for SHOX2

Target: SHOX2 (Short Stature Homeobox 2 (SHOX2))

Alternative Name: SHOX2 / SHOT (SHOX2 Products)

Background: SHOX2 is a member of the homeo box family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeo box genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeo box genes. SHOX is a pseudoautosomal homeo box gene that is thought to be responsible for idiopathic short stature and implicated to play a role in the short stature phenotype of Turner syndrome patients. This gene is a member of the homeo box family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeo box genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeo box genes. SHOX is a pseudoautosomal homeo box gene that is thought to be responsible for idiopathic short stature and implicated to play a role in the short stature phenotype of Turner syndrome patients. This gene is considered to be a candidate gene for Cornelia de Lange syndrome. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.Synonyms: Homeobox protein Og12X, OG12X, Paired-related homeobox protein SHOT, Short stature homeobox protein 2

Gene ID: 6474

NCBI Accession: NP_006875

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development