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CD68 antibody (FITC)

This Mouse Monoclonal antibody specifically detects CD68 in FACS. It exhibits reactivity toward Human.
Catalog No. ABIN112006

Quick Overview for CD68 antibody (FITC) (ABIN112006)

Target

See all CD68 Antibodies
CD68 (CD68 Molecule (CD68))

Reactivity

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Human

Host

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Mouse

Clonality

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Monoclonal

Conjugate

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This CD68 antibody is conjugated to FITC

Application

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Flow Cytometry (FACS)

Clone

Ki-M7
  • Specificity

    CD68 antibody BM4111F recognizes the 110KD integral membrane glycoprotein CD68 (Macrosialin) predominantly expressed on the intracellular lysosomes of monocytes and macrophages and to a lesser extent by dendritic cells and peripheral blood granulocytes.

    Characteristics

    Absorption / Emission: 495 nm / 528 nm

    Purification

    Protein A Chromatography

    Immunogen

    Cell suspensions of Human lymph node

    Isotype

    IgG1
  • Application Notes

    Flow Cytometry: Use 10 μL to label 10^6 cells in 100 μL (Membrane permeabilisation isrequired). Clone KiM7 has been reported as being also suitable for use in Immunoprecipitation andImmunohistochemistry on Frozen Sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    Restrictions

    For Research Use only
  • Buffer

    PBS, 0.05 % Sodium Azide, 1 % BSA

    Preservative

    Sodium azide

    Precaution of Use

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C

    Storage Comment

    Store the antibody undiluted at 2-8 °C.
  • Target

    CD68 (CD68 Molecule (CD68))

    Alternative Name

    CD68

    Background

    The CD68 antigen is a 37kD transmembrane protein that is post-translationally glycosylated to give a protein of 87-115kD. CD68 is specifically expressed by tissue macrophages, Langerhans cells and at low levels by dendritic cells. It could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin bearing substrates or other cells. Elevated expression of CD68 has been demonstrated on CD34+ cells in various human malignancies, including several Acute Myeloid Leukaemia studies.Synonyms: Gp110, Macrophage marker, Macrosialin

    Gene ID

    968

    NCBI Accession

    NP_001035148

    UniProt

    P34810
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