DLK1 antibody (Extracellular Domain)

Catalog No. ABIN1169190

This anti-DLK1 antibody is a Rat Monoclonal antibody detecting DLK1 in WB and ELISA. Suitable for Mouse. This Primary Antibody has been cited in 1 publication.

Quick Overview for DLK1 antibody (Extracellular Domain) (ABIN1169190)

Target: DLK1 (delta-Like 1 Homolog (Drosophila) (DLK1))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This DLK1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: PF105B

Product Details anti-DLK1 Antibody

Binding Specificity: Extracellular Domain

Specificity: Recognizes mouse DLK1.

Cross-Reactivity: Mouse (Murine)

No Cross-Reactivity: Human

Cross-Reactivity (Details): Does not cross-react with human DLK1.

Sterility: 0.2 μm filtered

Immunogen: Recombinant mouse DLK1 (extracellular domain).

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.

Preservative: Without preservative

Storage: 4 °C,-20 °C

Storage Comment: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Expiry Date: 12 months

References for anti-DLK1 antibody (ABIN1169190)

Kim, Kang, Park, Kim, Park, Kim, Leem, Chu, Lee, Jho, Oh: "Identification of a stroma-mediated Wnt/beta-catenin signal promoting self-renewal of hematopoietic stem cells in the stem cell niche." in: Stem cells (Dayton, Ohio), Vol. 27, Issue 6, pp. 1318-29, (2009) (PubMed).

Target Details for DLK1

Target: DLK1 (delta-Like 1 Homolog (Drosophila) (DLK1))

Alternative Name: DLK1

Background: The transmembrane and secreted protein delta-like 1 homolog (DLK1, Protein delta homolog 1, Preadipocyte factor 1, Pref-1) belongs to the EGF-like family. It can be cleaved by a tumor necrosis factor-alpha converting enzyme (TACE) to release a soluble form. DLK1 plays important roles in regulating cell differentiation such as adipogenesis and osteogenesis. Membrane-bound DLK1 promotes hypertrophic myotube formation, whereas soluble DLK1 inhibits myotube formation. The soluble form of DLK1 inhibits preadipocyte differentiation, while membrane DLK1 represses preadipocyte proliferation. DLK1 is also associated with tumor invasion.

UniProt: Q09163