CTRP6 antibody (Globular Domain, Globular Domain-less)

Catalog No. ABIN1169274

Product Details anti-CTRP6 Antibody

Target: CTRP6 (C1QTNF6) (Complement C1q Tumor Necrosis Factor-Related Protein 6 (C1QTNF6))

Binding Specificity: Globular Domain, Globular Domain-less

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CTRP6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: Recognizes the N-terminal half of human CTRP6 full-length protein. Detects bands of ~16 kDa and ~32 kDa by Western blot.

Cross-Reactivity: Human

Purification: Purified from concentrated hybridoma tissue culture supernatant.

Sterility: 0.2 μm filtered

Immunogen: Recombinant human CTRP6 (globular domain-less).

Clone: 256-E

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.

Preservative: Without preservative

Storage: 4 °C,-20 °C

Storage Comment: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Expiry Date: 12 months

Target Details for CTRP6

Target: CTRP6 (C1QTNF6) (Complement C1q Tumor Necrosis Factor-Related Protein 6 (C1QTNF6))

Alternative Name: CTRP6 (C1QTNF6 Products)

Background: CTRP6 mediates the phosphorylation of AMPK and acetyl-CoA carboxylase (ACC) in skeletal muscle cells, subsequently mediating glycogen accumulation and fatty acid oxidation. It induces the expression of the potent anti-inflammatory cytokine IL-10 in macrophages. CTRP6 may be a potential serum marker for hepatocellular carcinoma, contributing to tumor angiogenesis by activating the Akt pathway. CTRP6 was also shown to be associated with obesity, type 1 diabetes mellitus (T1D), vitiligo (depigmentation of the skin) and ASFV (African Swine Fever Virus). CTRP6 forms homotrimers and higher-order oligomers and it may also form heteromeric complexes with CTRP1. May be involved in kidney inflammation.

UniProt: Q9BXI9