CysLTR1 antibody (3rd Extracellular Domain)

Catalog No. ABIN122043

This anti-CysLTR1 antibody is a Rabbit Polyclonal antibody detecting CysLTR1 in IHC (p). Suitable for Human, Mouse and Rat.

Quick Overview for CysLTR1 antibody (3rd Extracellular Domain) (ABIN122043)

Target: CysLTR1 (CYSLTR1) (Cysteinyl Leukotriene Receptor 1 (CYSLTR1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CysLTR1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CysLTR1 Antibody

Binding Specificity: 3rd Extracellular Domain

Specificity: Reacts with Cysteinyl Leukotriene Receptor 1(Family: GPCR, Subfamily: Chemoattractant).

Characteristics: Synonyms: Cysteinyl leukotriene receptor 1, CysLTR1, LTD4 receptor, HG55, HMTMF81, Cysteinylleukotriene D4 receptor, G-protein coupled receptor HG55

Purification: Peptide immunogen affinity column

Immunogen: Synthetic peptide - KLH conjugatedEpitope: 3rd extracellular domain of humanGenename: CYSLTR1Remarks: The immunizing peptide shows 80 % identity (85 % similarity) with mouse and75 % identity (90 % similarity) with rat.

Application Details

Application Notes: Immunohistochemistry with formalin fixed paraffin embedded tissues: 6 -14g/mL. Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100C for 20 min. Remove fromheat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween(TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, containing 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-80 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -70 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CysLTR1

Target: CysLTR1 (CYSLTR1) (Cysteinyl Leukotriene Receptor 1 (CYSLTR1))

Alternative Name: CYSLTR1

Background: Cysteinyl leukotriene receptor 1, a Chemoattractant Receptor, is detected in spleen, peripheral blood leukocytes, and lung smooth muscle (Lynch et al., 1999). It binds cysteinyl leukotrienes, which are neutrophil chemoattractants with potent proinflammatory action. Leukotrienes mediate many features of bronchial asthma such as edema, bronchial constriction, and hyperreactivity (Bisgaard et al., 2000). Selective CysLT1 antagonists are used to treat asthma. The cysteinyl leukotrienes, leukotriene C4 (LTC4), leukotriene D4 (LTD4), and leukotriene E4 (LTE4) activate at least two receptors, CysLT1 and CysLT2, to mediate human bronchial asthma. LTC(4), LTD(4), and LTE(4) are a class of peptide-conjugated lipids formed from arachidonic acid and that are released during activation of mast cells.Synonyms: CysLTR1, Cysteinyl leukotriene D4 receptor, Cysteinyl leukotriene receptor 1, G-protein coupled receptor HG55, HG55, HMTMF81, LTD4 receptor

Gene ID: 10800

UniProt: Q9Y271