ANK2 antibody (AA 203-496)

Catalog No. ABIN1304533

This Mouse Monoclonal antibody specifically detects ANK2 in IHC, WB, ICC and IP. It exhibits reactivity toward Human.

Quick Overview for ANK2 antibody (AA 203-496) (ABIN1304533)

Target: ANK2 (Ankyrin 2, Neuronal (ANK2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ANK2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Clone: N105-17

Product Details anti-ANK2 Antibody

Binding Specificity: AA 203-496

Specificity: No off-targets reported

Cross-Reactivity: Guinea Pig, Human, Mouse, Rat

Characteristics:

Description: Our Anti-Ankyrin-B mouse monoclonal primary antibody is produced in-house from hybridoma clone N105/17. It detects human, mouse, and rat Ankyrin-B, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Manufacturer Comment: We produce our Ankyrin-B mouse monoclonal primary antibody from hybridoma clone N105/17. It is great in IHC, ICC, WB and is purified by Protein A chromatography.

Purification: Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography.

Purity: > 90% specific antibody

Immunogen: Fusion protein amino acids 203-496 of human Ankyrin-B (accession number Q01484) produced recombinantly in E. Coli

Isotype: IgG2a

Application Details

Application Notes:

Dilution Range: IHC: 1:500

Dilution Range: ICC: 1:500

Dilution Range: WB: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 10 mM Tris, 50 mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Storage: 4 °C,-20 °C

Storage Comment: Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Expiry Date: 24 months

Target Details for ANK2

Target: ANK2 (Ankyrin 2, Neuronal (ANK2))

Alternative Name: Ankyrin-B

Background:

Synonyms: Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin)

Target Description: Ankyrin-2 or -Ankyrin-B is encoded by the gene ANK2. Ankyrin B is a scaffold protein that functions to link proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane cytoskeleton. In this manner, ankyrin family proteins play key roles in various processes including cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Ankyrin B is expressed in brain and muscle. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome.

Gene Name Alternatives: ANK2 ANKB

Molecular Weight: < 200 kDa

UniProt: Q01484

Pathways: Cell-Cell Junction Organization