KCNU1 antibody (AA 1052-1121)

Catalog No. ABIN1304964

Product Details anti-KCNU1 Antibody

Target: KCNU1 (Potassium Channel, Subfamily U, Member 1 (KCNU1))

Binding Specificity: AA 1052-1121

Reactivity: Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This KCNU1 antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunoprecipitation (IP), Immunoelectron Microscopy (IEM)

Specificity: No off-targets reported

Cross-Reactivity: Mouse, Xenopus laevis

Characteristics:

Description: Our Anti-KCNU1/Slo3 pH -sensitive maxi-K+ channel mouse monoclonal primary antibody is produced in-house from hybridoma clone N2/16. It is KO validated, detects mouse, Xenopus KCNU1/Slo3 pH -sensitive maxi-K+ channel, and is purified by Protein A chromatography. It is great for use in EM, ICC, IP, WB.

Manufacturer Comment: We produce our KCNU1/Slo3 pH -sensitive maxi-K+ channel mouse monoclonal primary antibody from hybridoma clone N2/16. It is great in EM, ICC, IP, WB and is purified by Protein A chromatography.

Purification: Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography.

Purity: > 90% specific antibody

Immunogen: Fusion protein amino acids 1052-1121 of mouse Slo3 (accession number O54982) produced recombinantly in E. Coli

Clone: N2-16

Isotype: IgG1

Application Details

Application Notes:

Dilution Range: IP: 5 μg

Dilution Range: WB: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 10 mM Tris, 50 mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Storage: 4 °C,-20 °C

Storage Comment: Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Expiry Date: 24 months

Target Details for KCNU1

Target: KCNU1 (Potassium Channel, Subfamily U, Member 1 (KCNU1))

Alternative Name: KCNU1 (KCNU1 Products)

Background:

Synonyms: Potassium channel subfamily U member 1 (Calcium-activated potassium channel subunit alpha-3) (Calcium-activated potassium channel, subfamily M subunit alpha-3) (Pore-forming subunit of the sperm-specific alkalization activated K(+) current) (KSper) (Slowpoke homolog 3) (mSlo3) ( pH -sensitive maxi potassium channel)

Target Description: Potassium calcium-activated channel subfamily U member 1 is encoded by the gene KCNU1. KCNU1 is a member of the potassium channel family, calcium-activated (TC 1.A.1.3) subfamily, KCa5.1/KCNU1 sub-subfamily. KCNU1 is a testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates transport of K+. KCNU1 is expressed in the testis. Diseases associated with KCNU1 include Leukodystrophy, Hypomyelinating, 3 and Coffin-Siris Syndrome 1.

Gene Name Alternatives: Kcnu1 Kcnma3 Ksper Slo3

Molecular Weight: 115 kDa