KLF1/2/4 antibody (AA 279-303)
Quick Overview for KLF1/2/4 antibody (AA 279-303) (ABIN1386255)
Target
Reactivity
Host
Clonality
Conjugate
Application
-
-
Binding Specificity
- AA 279-303
-
Cross-Reactivity
- Human, Mouse, Rat
-
Purification
- Purified by Protein A.
-
Immunogen
- KLH conjugated synthetic peptide derived from human KLF1
-
Isotype
- IgG
-
-
-
-
Application Notes
-
WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200 -
Restrictions
- For Research Use only
-
-
-
Format
- Liquid
-
Concentration
- 1 μg/μL
-
Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
-
Preservative
- ProClin
-
Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
-
Storage
- 4 °C,-20 °C
-
Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
-
Expiry Date
- 12 months
-
-
- KLF1/2/4 (Kruppel-Like Factor 1/2/4 (KLF1/2/4))
-
Background
-
Synonyms: EKLF, INLU, CDAN4, HBFQTL6, Krueppel-like factor 1, Erythroid krueppel-like transcription factor, KLF1
Background: Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation (By similarity).
-
Gene ID
- 10661
-
UniProt
- Q13351
Target
-
