BRMS1 antibody (AA 151-246)

Catalog No. ABIN1386878

The Rabbit Polyclonal anti-BRMS1 antibody has been validated for WB, ELISA, IF (cc), IF (p), ICC, IHC (p) and IHC (fro). It is suitable to detect BRMS1 in samples from Human, Mouse and Rat.

Quick Overview for BRMS1 antibody (AA 151-246) (ABIN1386878)

Target: BRMS1 (Breast Cancer Metastasis Suppressor 1 (BRMS1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BRMS1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-BRMS1 Antibody

Binding Specificity: AA 151-246

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human BRMS1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for BRMS1

Target: BRMS1 (Breast Cancer Metastasis Suppressor 1 (BRMS1))

Alternative Name: BRMS1

Background:

Synonyms: Breast cancer metastasis suppressor 1, Breast cancer metastasis-suppressor 1, BRMS-1, BRMS1_HUMAN, DKFZp564A063, MGC95128, AV003220, AW554636.

Background: Breast cancer metastasis-suppressor 1 (BRMS1) is 246 amino acid protein that acts as a mediator of metastasis suppression in several types of cancer including ovarian, lung, bladder, and murine mammary. BRMS1 mRNA is expressed in various tissues, including ovary, prostate, testis, and colon, but the protein is primarily detected in term placenta. BRMS1 suppresses metastasis without inhibiting tumorigenicity by modifying several metastasis-associated phenotypes. BRMS1 may participate in transcriptional regulation by binding to the mSin3/histone deacetylase complex. The expression of BRMS1 in certain cells increases connexin Cx43 expression and reduces connexin Cx32 expression. This produces a gap junction that increases intercellular communication, similar to those found in normal breast tissue. BRMS1 is stabilized by Hsp90 and may inhibit NF-_B activity.