ESYT1 antibody (AA 651-750)

Catalog No. ABIN1387363

This Rabbit Polyclonal antibody specifically detects ESYT1 in WB, ELISA, IHC (p), ICC, IF (cc), IF (p) and IHC (fro). It exhibits reactivity toward Human and Mouse.

Quick Overview for ESYT1 antibody (AA 651-750) (ABIN1387363)

Target: ESYT1 (Extended Synaptotagmin-Like Protein 1 (ESYT1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ESYT1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-ESYT1 Antibody

Binding Specificity: AA 651-750

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Dog,Cow,Pig,Horse,Rabbit,Monkey

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ESYT1/FAM62A

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for ESYT1

Target: ESYT1 (Extended Synaptotagmin-Like Protein 1 (ESYT1))

Alternative Name: ESYT1/FAM62A

Background:

Synonyms: Extended synaptotagmin 1, KIAA0747, E Syt1, E-Syt1, Esyt1, ESYT1_HUMAN, Extended synaptotagmin like protein 1, Extended synaptotagmin-1, Family with sequence similarity 62 C2 domain containing member A, Family with sequence similarity 62 member A, MBC2, Membrane bound C2 domain containing protein, Membrane-bound C2 domain-containing protein, Protein FAM62A.

Background: Encoding over 1,100 genes within 132 million bases, chromosome 12 makes up about 4.5 % of the human genome. A number of skeletal deformities are linked to chromosome 12 including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan syndrome, which includes heart and facial developmental defects among the primary symptoms, is caused by a mutant form of PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy. The FAM62A gene product has been provisionally designated FAM62A pending further characterization.