H13 antibody (AA 251-350) (Biotin)

Catalog No. ABIN1389739

This Rabbit Polyclonal antibody specifically detects H13 in WB, ELISA, IHC (fro) and IHC (p). It exhibits reactivity toward Human.

Quick Overview for H13 antibody (AA 251-350) (Biotin) (ABIN1389739)

Target: H13 (Histocompatibility 13 (H13))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This H13 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-H13 Antibody (Biotin)

Binding Specificity: AA 251-350

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Signal Peptide Peptidase

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for H13

Target: H13 (Histocompatibility 13 (H13))

Alternative Name: Spp/Signal Peptide Peptidase

Background:

Synonyms: Histocompatibility minor 13, HM 13, HM13, HM13_HUMAN, IMP 1, IMP-1, IMP1, IMPAS, IMPAS-1, Intramembrane Protease 1, Intramembrane protease, Minor Histocompatibility 13, Minor histocompatibility antigen 13, Minor histocompatibility antigen H13, MSTP086, Presenilin like protein 3, Presenilin-like protein 3, PSENL 3, PSENL3, PSL 3, PSL3, Signal peptide peptidase, Signal peptide peptidase beta, SPP, dJ324O17.1, H13, hIMP1, hIMP1 protein.

Background: The endoplasmic reticulum exerts a quality control over newly synthesized proteins and a variety of components have been implicated in the specific recognition of aberrant or misfolded polypeptides. Signal peptide peptidase (SPP) catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. SPP is required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides, and may play a role in graft rejection. It also may be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein.

Gene ID: 207