Humanin antibody (AA 1-24) (Biotin)

Catalog No. ABIN1392505

This Rabbit Polyclonal antibody specifically detects Humanin in IHC (fro) and IHC (p). It exhibits reactivity toward Human.

Quick Overview for Humanin antibody (AA 1-24) (Biotin) (ABIN1392505)

Target: Humanin (MT-RNR2) (Mitochondrially Encoded 16S RNA (MT-RNR2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Humanin antibody is conjugated to Biotin

Application: Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Humanin Antibody (Biotin)

Binding Specificity: AA 1-24

Predicted Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Humanin

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C

Expiry Date: 12 months

Target Details for Humanin

Target: Humanin (MT-RNR2) (Mitochondrially Encoded 16S RNA (MT-RNR2))

Alternative Name: Humanin

Background:

Humanin, an endogenous anti-apoptotic peptide against Alzheimer disease-related insults, consists of 24 amino acids. The secreted protein is a neuroprotective factor against death induced by several different types of Alzheimer's disease genes. Humanin protects neuronal cells from damage caused by Alzheimer's disease genes, specifically APP (amyloid precursor protein). Humanin acts as a ligand for formyl peptide receptor-like 1 (FPRL1) with APP and utilizes its neuroprotective effects by inhibiting FPRL1 access to APP. The peptide prevents Bax translocation from cytosol to mitochondria. Humanin expression levels may be dependent on defects in energy production in muscles with mitochondrial abnormalities. The peptide has been detected in muscles of patients with the mitochondrial disease chronic progressive external ophthalmoplegia (CPEO). Humanin is mainly expressed in the kidney, heart, liver, testis and skeletal muscles.

Subcellular location: Secreted

Synonyms: HN,HUNIN, HUNIN_HUMAN.