CADPS antibody (AA 151-250) (Biotin)

Catalog No. ABIN1393471

This Rabbit Polyclonal antibody specifically detects CADPS in IHC (fro). It exhibits reactivity toward Human.

Quick Overview for CADPS antibody (AA 151-250) (Biotin) (ABIN1393471)

Target: CADPS (Ca++-Dependent Secretion Activator (CADPS))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CADPS antibody is conjugated to Biotin

Application: Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-CADPS Antibody (Biotin)

Binding Specificity: AA 151-250

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CAPS1

Isotype: IgG

Application Details

Application Notes: IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for CADPS

Target: CADPS (Ca++-Dependent Secretion Activator (CADPS))

Alternative Name: CAPS1

Background:

Synonyms: Cadps, CADPS1, Calcium dependent secretion activator 1, Calcium-dependent activator protein for secretion 1, Calcium-dependent secretion activator 1, Caps, CAPS-1, rCAPS, CAPS1_HUMAN.

Background: Calcium-dependent secretion activators (CAPS-1 and CAPS-2) are calcium-binding proteins that direct neurotransmitter and neuropeptide-filled vesicles to the cell membrane for secretory granule exocytosis. Both CAPS-1 and CAPS-2 are expressed primarily in the brain where they regulate the secretion of various substances. The CAPS proteins contain a PH domain that is essential for regulation of exocytosis, as well as regulation of phospholipid binding. Through their regulation of neurotrophin release from granule cells, CAPS proteins help to regulate cell fate during neuronal development. CAPS-1 is thought to regulate catecholamine release from neuronal cells, while CAPS-2 is thought to regulate release of both brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) from granule cells. Defects in the genes encoding CAPS-1 and CAPS-2 are implicated in impaired cerebral development and autism.

Pathways: Synaptic Vesicle Exocytosis